ID A0A3B6MSE6_WHEAT Unreviewed; 982 AA.
AC A0A3B6MSE6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Glutamate receptor {ECO:0000256|PIRNR:PIRNR037090};
GN ORFNames=CFC21_077726 {ECO:0000313|EMBL:KAF7072619.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5D02G226100.1};
RN [1] {ECO:0000313|EMBL:KAF7072619.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7072619.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5D02G226100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5D02G226100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5D02G226100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7072619.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7072619.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as non-selective
CC cation channel. {ECO:0000256|PIRNR:PIRNR037090}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685, ECO:0000256|PIRNR:PIRNR037090}.
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DR EMBL; CM022225; KAF7072619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6MSE6; -.
DR SMR; A0A3B6MSE6; -.
DR STRING; 4565.A0A3B6MSE6; -.
DR EnsemblPlants; TraesCS5D02G226100.1; TraesCS5D02G226100.1; TraesCS5D02G226100.
DR Gramene; TraesCAD_scaffold_022264_01G000200.1; TraesCAD_scaffold_022264_01G000200.1; TraesCAD_scaffold_022264_01G000200.
DR Gramene; TraesCLE_scaffold_032087_01G000200.1; TraesCLE_scaffold_032087_01G000200.1; TraesCLE_scaffold_032087_01G000200.
DR Gramene; TraesCS5D02G226100.1; TraesCS5D02G226100.1; TraesCS5D02G226100.
DR Gramene; TraesCS5D03G0528300.1; TraesCS5D03G0528300.1.CDS; TraesCS5D03G0528300.
DR Gramene; TraesKAR5D01G0241410.1; cds.TraesKAR5D01G0241410.1; TraesKAR5D01G0241410.
DR Gramene; TraesPAR_scaffold_001557_01G000500.1; TraesPAR_scaffold_001557_01G000500.1; TraesPAR_scaffold_001557_01G000500.
DR Gramene; TraesRN5D0100552300.1; TraesRN5D0100552300.1; TraesRN5D0100552300.
DR Gramene; TraesROB_scaffold_014914_01G000500.1; TraesROB_scaffold_014914_01G000500.1; TraesROB_scaffold_014914_01G000500.
DR Gramene; TraesWEE_scaffold_026018_01G000200.1; TraesWEE_scaffold_026018_01G000200.1; TraesWEE_scaffold_026018_01G000200.
DR OMA; WTFMELA; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000019116; Chromosome 5D.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF566; GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037090-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|PIRNR:PIRNR037090};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|PIRNR:PIRNR037090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037090};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037090};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037090}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..982
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039993354"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 650..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 475..812
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT REGION 883..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..982
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 761..816
FT /evidence="ECO:0000256|PIRSR:PIRSR037090-50"
SQ SEQUENCE 982 AA; 109289 MW; E6192BC16F2DF981 CRC64;
MTTAPVLLRL RASMPALRRH GRLLVLLLLL IGAYGAAAQG GGVAPRRRRQ VVDVGVILDT
KTWVGNISWT FMELALDDFY ADDSHARFRT RLKLHLRDTG PGVVDAASAG VDLLQNVRVQ
AIVGPQTSTQ AKFLAELGNK STVPIISFSA DCPSRSGLTP YFIRTAWNDS SQAEAIASLV
QKYNWREVVP VYEDDDDTNI KFIPDLVDAL KQVDTRVSYR CKIHPSATED DMKTAISNLK
QNWTSVFVVR MSHALAQKFF QLAKDEGMMA QGFVWITAYG LTDIFDVVGS PALDVMQGVL
GVKPHVQDTV ELQNFRQRWR KKYRLENPGT SLSEPTVSGL YAYDTIWALA LAAEKAGFVN
SDFRPSLTKN VSTDFDRIDT SKAAEKLRGA LLKVLFFGIS GKFHIKDMQL VSSNYTIINV
VGQERREVGF WTPGSGISGS PKMKSDLNTI VWPGYNETAP TAPRGWLFPT NKNLTIGMPV
KPGFEEFVRF ENGKATGFCV DVFEAVVKEL SYDVPRHYEQ FGDGEGSSNG TYDELVYEVY
LKRYDAVVGD ITILANRSSY VDFTLPYTES GVRMLVPVQD RRQKTAWTFL RPLTADLWLG
TGAFFIFTGF VVWSIEHRIN QDFRGSPASQ IGSVFYFSFS TLVFAHREQI LNNLSRIAIV
VWLFVVLIVQ QSYTASLSSI LTVEQLQPTV TNLEEVVRNG GNVGYLNDSF LPGLLKRLKI
DESKMIAFDS PVEYDEALSS GKVAVIVDEI PYLKVFLSKY CQKYTMVGPT YKFDGFGYAF
PRGSPLTPDI SRGILKFASD DRMVKMQKDL YGETSCPDKD DSQTSSSLTL HSFKGLFIIS
GASSVLALIL HAAITIYNNR HEFNSDNSQS PWRRWPAILS KLFHGDDSPS NTPDKDEAAA
ENVGSAVETP LSIRIPSHIV EHLSDTDTGS PPEGEGTPGR ELSVQDTEPL SFAYMHSERE
QNRAASLSRS GSSIRRRQIS ME
//
