ID A0A3B6MVG7_WHEAT Unreviewed; 1007 AA.
AC A0A3B6MVG7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_079185 {ECO:0000313|EMBL:KAF7074287.1}, CFC21_079187
GN {ECO:0000313|EMBL:KAF7074288.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS5D02G366600.1};
RN [1] {ECO:0000313|EMBL:KAF7074287.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7074287.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS5D02G366600.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5D02G366600.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5D02G366600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7074287.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7074287.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022225; KAF7074287.1; -; Genomic_DNA.
DR EMBL; CM022225; KAF7074288.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6MVG7; -.
DR SMR; A0A3B6MVG7; -.
DR STRING; 4565.A0A3B6MVG7; -.
DR EnsemblPlants; TraesCS5D02G366600.1; TraesCS5D02G366600.1; TraesCS5D02G366600.
DR Gramene; TraesCS5D02G366600.1; TraesCS5D02G366600.1; TraesCS5D02G366600.
DR Gramene; TraesCS5D03G0824000.1; TraesCS5D03G0824000.1.CDS; TraesCS5D03G0824000.
DR OMA; FPATTIM; -.
DR Proteomes; UP000019116; Chromosome 5D.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1116; OS11G0657900 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 46..130
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 231..466
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 967..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..995
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114778 MW; 21120074B3E8DE7E CRC64;
MHMQTTHSKI STYCVCVCVC VRERERERER EREREREREM QVVTGAIGSL LPKLGKLLME
EYNLQKKAKK GVESLMREMK TIHAALCKVA DVASDQLDEQ VKLWADEVRE LSYDMEDVVD
KFLVRVDGSN KPADDGNKLT NLVEKMANLF NNGKARRQIS SAIKNIQKDV QDVAARRGRY
TVDDIVPKPT ARTAIDPRLR ALYTEVTELV GIYGKRDQEL VKLLSLGDED LCKKRLKIVS
VVGFGGLGKT TLVRTVYDKI KGGFHSWAFV PVGRNPDVKK IFRDILIGLN KQIYTNINLM
ALDERQLIEE IRELLQDKRY LVVIDDIWDS KLWGDIKLAF SNMNNFGSRL ITTTRILSVS
KACCPSTHDS IYEMKPLSDD DSARLFYKRI FSSENGCPNE LKKVSKDILR KCGGVPLAIL
TIASLLATVQ QIKPKFEWHV LVNSIGRGLT EDASMEEMQR ILSFSYYDLP SDMKTCLLYL
SMYPEDREID KEELIWKWIC EEFVQHGKQL TSTFEIGETY FNELINRNMI QPIYTGFCEV
KSCRVHDMVL DLIRSLSGEA KFITVLDSNK DMTCCRGNIR RISLQNIELD PRTTPLINSS
SMSQVRSITA FFPATTIMPA LSSFEVLRVL DLSGCNLGAV NCQVNLRDIV HLFHLRYLGL
RRTGICELPK EIGNLQFLQV IDAQYNFDMR VLPSSMCKLR KLMVVKVLIC CNWTPGVLGN
LTSLQVLERI SASPSIVQEL GNLARLRELE IHFLHRSPEL EEAFVESICK LNDIQSLNIN
YQDSPYLDLL GERWVPPRCL GKFEFYSDHM ACSTLPMWIR RCGPSHLSNL STFSIIIKEV
RQEDVQILGR LHSLRHLWMQ STHQTERLLV IGADGFRLTI AFALHCQPAT QVVFQQGALP
NAEQVRFNLG VRVAKEDGNG DCFELGLLNL LSLQSAIVEI HWDGIIVKEA EKAEAAVRNA
LNAHPNQPSI AFSMEPYIPE DTDDDDDDDY YDDDIDTDVQ GKRMDLD
//
