ID A0A3B6NMU3_WHEAT Unreviewed; 453 AA.
AC A0A3B6NMU3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=W2 domain-containing protein {ECO:0000259|PROSITE:PS51363};
GN ORFNames=CFC21_082582 {ECO:0000313|EMBL:KAF7078100.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6A02G119100.1.cds1};
RN [1] {ECO:0000313|EMBL:KAF7078100.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7078100.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6A02G119100.1.cds1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6A02G119100.1.cds1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6A02G119100.1.cds1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7078100.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7078100.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM022226; KAF7078100.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6NMU3; -.
DR SMR; A0A3B6NMU3; -.
DR STRING; 4565.A0A3B6NMU3; -.
DR PaxDb; 4565-Traes_6AS_CB50110091-1; -.
DR EnsemblPlants; TraesCS6A02G119100.1; TraesCS6A02G119100.1.cds1; TraesCS6A02G119100.
DR Gramene; TraesCAD_scaffold_040669_01G000100.1; TraesCAD_scaffold_040669_01G000100.1; TraesCAD_scaffold_040669_01G000100.
DR Gramene; TraesCLE_scaffold_054910_01G000100.1; TraesCLE_scaffold_054910_01G000100.1; TraesCLE_scaffold_054910_01G000100.
DR Gramene; TraesCS6A02G119100.1; TraesCS6A02G119100.1.cds1; TraesCS6A02G119100.
DR Gramene; TraesCS6A03G0280000.1; TraesCS6A03G0280000.1.CDS1; TraesCS6A03G0280000.
DR Gramene; TraesKAR6A01G0061370.1; cds.TraesKAR6A01G0061370.1; TraesKAR6A01G0061370.
DR Gramene; TraesPAR_scaffold_026412_01G000300.1; TraesPAR_scaffold_026412_01G000300.1; TraesPAR_scaffold_026412_01G000300.
DR Gramene; TraesRN6A0100248300.1; TraesRN6A0100248300.1; TraesRN6A0100248300.
DR OMA; SYINIPR; -.
DR OrthoDB; 5475947at2759; -.
DR Proteomes; UP000019116; Chromosome 6A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0071074; F:eukaryotic initiation factor eIF2 binding; IBA:GO_Central.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF7; EUKARYOTIC TRANSLATION INITIATION FACTOR 5; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 300..453
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 145..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 49060 MW; BBC7DC3330E0006F CRC64;
MALQNIGASN KDDAFYRYKM PRMLTKIEGR GNGIKTNIVN MVDIAKALAR PASYTTKYFG
CELGAQSKFD EKTGISLVNG AHDTSKLAGL LENFIKKYVQ CYGCGNPETE VLISKKEMIT
LKCAACGFLS DVDMRDKLTT FILKNPPEAK KGGKDKKAMR RAEKERLKEG EAADEEMKKL
KKDGKKKGAS SKESTAKGVA TKKKGAGGSD EEHISSPRDA DFAAAADDDD DDDDDVQWAT
DTSAEAARKR MEEQLSAATA EMVMLATEET EKKKKQAQHK DDGCANGTSK AEETSNGKQN
GAKATPYDEL VEEIKASLAN AATAAQLKGV LSSSTLPLKD VMDALFEALF HGAGKGFAKD
VVKNKKYLAA AVPDEAAQML LLQSIEAFCS KCSAEALKEL PVVLKALYDG DLLEEETIVQ
WYNEAVAAGK DSQVVKNAKP VVEWLESAES DEE
//
