ID A0A3B6NPI7_WHEAT Unreviewed; 974 AA.
AC A0A3B6NPI7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN ORFNames=CFC21_082988 {ECO:0000313|EMBL:KAF7078576.1}, CFC21_082991
GN {ECO:0000313|EMBL:KAF7078579.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6A02G158900.1};
RN [1] {ECO:0000313|EMBL:KAF7078576.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7078576.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6A02G158900.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6A02G158900.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6A02G158900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7078576.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7078576.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
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DR EMBL; CM022226; KAF7078576.1; -; Genomic_DNA.
DR EMBL; CM022226; KAF7078579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6NPI7; -.
DR SMR; A0A3B6NPI7; -.
DR STRING; 4565.A0A3B6NPI7; -.
DR PaxDb; 4565-Traes_6AS_6F306F27E-1; -.
DR EnsemblPlants; TraesCS6A02G158900.1; TraesCS6A02G158900.1; TraesCS6A02G158900.
DR Gramene; TraesCS6A02G158900.1; TraesCS6A02G158900.1; TraesCS6A02G158900.
DR Gramene; TraesCS6A03G0386200.1; TraesCS6A03G0386200.1.CDS; TraesCS6A03G0386200.
DR Gramene; TraesKAR6A01G0097830.1; cds.TraesKAR6A01G0097830.1; TraesKAR6A01G0097830.
DR Gramene; TraesPAR_scaffold_094902_01G000300.1; TraesPAR_scaffold_094902_01G000300.1; TraesPAR_scaffold_094902_01G000300.
DR Gramene; TraesROB_scaffold_010743_01G000100.1; TraesROB_scaffold_010743_01G000100.1; TraesROB_scaffold_010743_01G000100.
DR Gramene; TraesWEE_scaffold_088527_01G000100.1; TraesWEE_scaffold_088527_01G000100.1; TraesWEE_scaffold_088527_01G000100.
DR OMA; WECFFDE; -.
DR OrthoDB; 7279at2759; -.
DR Proteomes; UP000019116; Chromosome 6A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IBA:GO_Central.
DR GO; GO:0043682; F:P-type divalent copper transporter activity; IBA:GO_Central.
DR GO; GO:0055070; P:copper ion homeostasis; IBA:GO_Central.
DR CDD; cd00371; HMA; 3.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 3.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR NCBIfam; TIGR00003; copper ion binding protein; 1.
DR PANTHER; PTHR46594:SF2; COPPER-TRANSPORTING ATPASE HMA4; 1.
DR PANTHER; PTHR46594; P-TYPE CATION-TRANSPORTING ATPASE; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 3.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 3.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 313..335
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 538..557
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 577..598
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 899..922
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 928..948
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 30..96
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 104..170
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 179..245
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 105106 MW; 1715EEFF9BA49157 CRC64;
MEQNGESHLK EPLLHAADGA SAAAARVSPR KERTTRKVMF NVRGMSCGSW VVAGLKGVES
IQVSTLQGQA VVQYSPEETD ARTIKEAIED INFEVDELQE QEIAVCRLRI KGMACTSCSE
SIERALLMVP GVKKAAVGLA LEEAKVHFDP NITSRDLLIE AIEDAGFGAD LISYGDDVNK
MHLKLEGVSS PEDTKLIQSV LETVEGVNNV EWDTSGQTVT VAYDPDVTGP RLLIQRIQDA
AEPPKCFNAS LYSPPKQREV ERHHEIMSYR NQFLWSCLFS VPVFLFAMVL PMLPPSGDWL
FYKIYNNMTV GMLLRWLLCS PVQFIIGWRF YVGAYHALKR GYSNMDVLVA LGTNAAYFYS
VYIIVKALTS DTFEGQDLFE TSSMLVSFIL LGKYLEVVAK GKTSDALSKL TELAPETAVL
LTLEKDGSVI SEVEISTQLL QRNDFIKIVP GEKVPVDGVV IKGQSHVNES MITGEARPIA
KKPGDKVIGG TVNDNGFIIV KATHVGSETA LSQIVQLVEA AQLARAPVQR LADKISRFFV
PTVVVAAFLT WLGWFIPGQL HLYPQQWIPK AMDSFELALQ FGISVLVVAC PCALGLATPT
AVMVATGKGA SLGVLIKGGN ALEKAHKIKT IIFDKTGTLT KGKPSVVQTK TFSKIPLLEL
CDLTASAEAN SEHPLSKAIV EYTKKLREQY GSPSDHMMDS KDFEVHPGAG VSANVEGKLV
LVGNKRLMQE FEAPMSSEVE EYMSEMEDLA RTCVLVAIDR VICGALAVSD PLKPEAGRVI
SHLSSMGITS IMVTGDNWAT AKSIAKQVGI STVFAEIDPV GKAEKIKDLQ TQGLAVAMVG
DGVNDSPALA AADVGMAIGA GTDVAIEAAD IVLMKSSLVD VITAIDLSRK TLAKIRLNYV
WALGYNVLGM PIAAGVLFPF TGIRLPPWLA GACMAASSVS VVCSSLLLQL YKKPLHVEEV
PMTAGPGDGG SNLV
//