ID A0A3B6NQ87_WHEAT Unreviewed; 1002 AA.
AC A0A3B6NQ87;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_083490 {ECO:0000313|EMBL:KAF7079229.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6A02G205700.2};
RN [1] {ECO:0000313|EMBL:KAF7079229.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7079229.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6A02G205700.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6A02G205700.2};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6A02G205700.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7079229.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7079229.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM022226; KAF7079229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6NQ87; -.
DR SMR; A0A3B6NQ87; -.
DR STRING; 4565.A0A3B6NQ87; -.
DR EnsemblPlants; TraesCS6A02G205700.2; TraesCS6A02G205700.2; TraesCS6A02G205700.
DR Gramene; TraesCS6A02G205700.2; TraesCS6A02G205700.2; TraesCS6A02G205700.
DR Proteomes; UP000019116; Chromosome 6A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0032389; C:MutLalpha complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 220..340
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 781..938
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 352..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1002 AA; 110780 MW; AC86D50A64AD0ADC CRC64;
MGGASPAIKP IGKTVVHRIC SGQVIFDLSS AVKELVENSL DAGATTVEVG LKAYGEEWFK
VADNGSGISP GNFQALALKH HTSKISDFSD LNSVVTFGFR GEALSSLCAL GKLTVETRTK
DESVGTHLEF EHSGVVISER KIARQVGTTV TIEKLFSTLP VRGKEFSRNI RKEYGKVISL
LHAYALIAKG VRLLCTNTVG KNSKMVVVKT QGSSSLKDNI ITVFGLNTFK CLEPFNLALS
EGCQVEGFLS KPGPGTGRNS GDRQFFYVNG RPVDMPKVTK LVNELYRSSN SRQYPVAVLN
FCIPTTSYDV NVAPDKRKIF FSSEHTILFS LREAIENLYS PQQCSFSINH IEDPEKVNHT
EDPVKEDDPM VDEPIKSTYL MDKENVSSPE NDNCKEDTDS DDQDPLKDQK VSSSATRVAT
GAASGDMSPL PRSPDTEVDR SPWFSALRYE QPKRPRADFR SNPVRENHVR TGLAAQSSPS
TIVQSSLMNF LSLNKRKHED SCNLITEAPV LRRGTCSGQV RRTSLEANAP GISDANSLQQ
ISLWDHSPQP FVPKRTEVSL QHSEPPNVGS PSTEAPVLRR GTCSGQVRRT SLEANAPGIS
DANSLQQISL WDHSPQPSVP KRTEVSLQHS EPPNVASPST EAHLLNPCDV HSTEFDDEQN
DRCLSNFGAP DQCLKDTEPP NTPSNITLLD GHDNDTSVCS TSVSYSVQFT IDELRRRRKR
GFIVSRENRV HCSEKTARCY KAATLDNYVP NDDEGKSNYL AAATNELDRF FSKDNFGEMK
VVGQFNLGFI IGKLEQDLFI VDQHAADEKY NFESLSQSTT LNIQPLLQPL RLELSPEEEV
IVSMHMNTIR KNGFVLAEDL HASPGSHYLL KAVPFSKNIT FGVQDVKELI CMLSDSQGDC
SIISSYKMDK TDSVCPSRVR AMFASRACRM STMIGDPLTK TEMKKILKNL TGLRSPWNCP
HGRPTMRHLA DLTSIRSKGK GLCSPLQHSF LFTWWFIARP SG
//
