ID A0A3B6NTK6_WHEAT Unreviewed; 360 AA.
AC A0A3B6NTK6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Cysteine proteinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_084196 {ECO:0000313|EMBL:KAF7080054.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6A02G279500.1};
RN [1] {ECO:0000313|EMBL:KAF7080054.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7080054.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6A02G279500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6A02G279500.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6A02G279500.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7080054.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7080054.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CM022226; KAF7080054.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6NTK6; -.
DR SMR; A0A3B6NTK6; -.
DR STRING; 4565.A0A3B6NTK6; -.
DR PaxDb; 4565-Traes_6AL_FD9CE49D6-2; -.
DR EnsemblPlants; TraesCS6A02G279500.1; TraesCS6A02G279500.1; TraesCS6A02G279500.
DR Gramene; TraesCAD_scaffold_015335_01G000300.1; TraesCAD_scaffold_015335_01G000300.1; TraesCAD_scaffold_015335_01G000300.
DR Gramene; TraesCLE_scaffold_070766_01G000300.1; TraesCLE_scaffold_070766_01G000300.1; TraesCLE_scaffold_070766_01G000300.
DR Gramene; TraesCS6A02G279500.1; TraesCS6A02G279500.1; TraesCS6A02G279500.
DR Gramene; TraesCS6A03G0743700.1; TraesCS6A03G0743700.1.CDS; TraesCS6A03G0743700.
DR Gramene; TraesKAR6A01G0310440.1; cds.TraesKAR6A01G0310440.1; TraesKAR6A01G0310440.
DR Gramene; TraesKAR6A01G0310440.2; cds.TraesKAR6A01G0310440.2; TraesKAR6A01G0310440.
DR Gramene; TraesWEE_scaffold_114028_01G000100.1; TraesWEE_scaffold_114028_01G000100.1; TraesWEE_scaffold_114028_01G000100.
DR OMA; MDCADDY; -.
DR OrthoDB; 340927at2759; -.
DR Proteomes; UP000019116; Chromosome 6A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF881; OS02G0715000 PROTEIN; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..360
FT /note="Cysteine proteinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039993873"
FT DOMAIN 50..106
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 134..349
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 360 AA; 39478 MW; B1CEA94711B33DEC CRC64;
MDSELSTVFF LLIVFAACCC SSSSATHHDP SVVGYSQEDV ALPSRILDLF SSWSVKHSRV
YVTPKEKVRR YEVFRQNLKH IVETNRRNGS YWLGLNQFAD VAHEEFKAGY LGLSAGGRPR
APTTAFRYEA AVDLTREVDW RKKGAVTPVK NQGKCGSCWA FSTVAAVEGI NQIVTGKLES
LSEQELMDCD STFDHGCGGG LMDFAYAYIV GNQGIHTDAD YPYLMEEGDC KENQPHSKVV
TISGYEDVPE NSELSLLKAL AHQPVSVGIA AGSRDFQFYK GGVFEGTCGT QLDHALTAVG
YGSSNGQDYI IMKNSWGGGW GEQGYFRIKR GTGRPEGVCD IYRIASYPTK NNGTGWGWGA
//
