ID A0A3B6NWJ3_WHEAT Unreviewed; 307 AA.
AC A0A3B6NWJ3;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Bidirectional sugar transporter SWEET {ECO:0000256|RuleBase:RU910715};
GN ORFNames=CFC21_085239 {ECO:0000313|EMBL:KAF7081277.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6A02G382500.1};
RN [1] {ECO:0000313|EMBL:KAF7081277.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7081277.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6A02G382500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6A02G382500.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6A02G382500.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7081277.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7081277.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates both low-affinity uptake and efflux of sugar across
CC the membrane. {ECO:0000256|RuleBase:RU910715}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SWEET sugar transporter family.
CC {ECO:0000256|ARBA:ARBA00007809, ECO:0000256|RuleBase:RU910715}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU910715}.
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DR EMBL; CM022226; KAF7081277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6NWJ3; -.
DR PaxDb; 4565-Traes_6AL_EAF53EB94-1; -.
DR EnsemblPlants; TraesCS6A02G382500.1; TraesCS6A02G382500.1; TraesCS6A02G382500.
DR Gramene; TraesCAD_scaffold_003033_01G000400.1; TraesCAD_scaffold_003033_01G000400.1; TraesCAD_scaffold_003033_01G000400.
DR Gramene; TraesCS6A02G382500.1; TraesCS6A02G382500.1; TraesCS6A02G382500.
DR Gramene; TraesCS6A03G0966500.1; TraesCS6A03G0966500.1.CDS; TraesCS6A03G0966500.
DR Gramene; TraesPAR_scaffold_044501_01G000100.1; TraesPAR_scaffold_044501_01G000100.1; TraesPAR_scaffold_044501_01G000100.
DR Gramene; TraesRN6A0100953600.1; TraesRN6A0100953600.1; TraesRN6A0100953600.
DR Gramene; TraesWEE_scaffold_005486_01G000100.1; TraesWEE_scaffold_005486_01G000100.1; TraesWEE_scaffold_005486_01G000100.
DR OMA; WICVAFA; -.
DR Proteomes; UP000019116; Chromosome 6A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR Gene3D; 1.20.1280.290; -; 2.
DR InterPro; IPR047664; SWEET.
DR InterPro; IPR004316; SWEET_rpt.
DR PANTHER; PTHR10791:SF22; BIDIRECTIONAL SUGAR TRANSPORTER SWEET12; 1.
DR PANTHER; PTHR10791; RAG1-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF03083; MtN3_slv; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910715};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597,
KW ECO:0000256|RuleBase:RU910715};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU910715};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU910715};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU910715}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910715"
FT TRANSMEM 48..66
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910715"
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910715"
FT TRANSMEM 173..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910715"
FT TRANSMEM 217..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU910715"
FT REGION 115..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33419 MW; CA577E064E708685 CRC64;
MAGLSLEHPW AFAFGLLGNI ISFTSLLAPI PTFYRIYKSK STEGFQSVPY VVALFSAMLW
IFYALVKSGE GLLITINAAG CVIETVYIVM YLVYAPRKAK VFTAKIILLL NIAASGSSSS
SPSSPSTARD ASSHSAGSAL ASPSWRDLLY VCQLTLMCSI PQGRVIKTKS VEYMPFSLSL
TLTLSAVVWF LYGLLIKDKY IRILFASMST DEWQLTFCLL LPNILGFTFG MIQMALYMFY
MNATPVVSDL KEGKEGMKMP AEEHVVVINV GKIEKSSGAV VRPVTAVPAA PGQQVMALDS
VRSVDVV
//
