ID A0A3B6PEA6_WHEAT Unreviewed; 965 AA.
AC A0A3B6PEA6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_085836 {ECO:0000313|EMBL:KAF7081934.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6B02G013300.2};
RN [1] {ECO:0000313|EMBL:KAF7081934.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7081934.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6B02G013300.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6B02G013300.2};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6B02G013300.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7081934.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7081934.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022227; KAF7081934.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6PEA6; -.
DR EnsemblPlants; TraesCS6B02G013300.2; TraesCS6B02G013300.2; TraesCS6B02G013300.
DR Gramene; TraesCS6B02G013300.2; TraesCS6B02G013300.2; TraesCS6B02G013300.
DR Gramene; TraesCS6B03G0029100.2; TraesCS6B03G0029100.2.CDS; TraesCS6B03G0029100.
DR Proteomes; UP000019116; Chromosome 6B.
DR Proteomes; UP000815260; Chromosome 6B.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1123; NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 12..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 171..302
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 940..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 946..965
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 106625 MW; F52065A923B5B922 CRC64;
MEAAVASALT KEVVLKLVTL LSEKHKLSKG LKGDLRFIHT ELDMILCDMD EHLGDPSHSS
RRPQVVSMEE MRDLAHDIED CIDRFLPCAA CEGEAASVLR RVKKAVTGNR SRFAAEIRKL
RQRVKDAHER RVNYGVNGVR SAAGAGAAAP PAVADAAEAD PVGIDRPRQE LVELLLGSEP
GPPGVISIVG FGGSGKTTLA RAVYCCPGVV QRFPARAWAA GSEHTYAGGL LTAILRQLRR
TVDVPQDQDS INNFLRTTEC LIVIDDVNKQ HWDAVRATFH RETKSRIIVT TALHSVANAC
SSGCSPELER GSTAIVDKCD GHPLALVSVA RFLLGKNELT GRHCTQVCRN LGLHMEEAAD
FTKLQQLLVN NYRSLSDYPL KTSLLYTSVF PNGRPIRKDT LIRRWLAEGY VQCRYKRSDL
EVADENFRKL VDRNIIRPID GSNNTKVKTC KTHGIMHEFM LHKSMSDNFI TSLHDQNRSK
FRHLFIQNPE GGSTLGLNHQ HTSPASDNIS GSSEKFRARS LTIFGNVGEA ASEFCRCELL
RVLDLEECDD LEDGHLKDIH KLWHLKYLSL GGAISNLPRN IEKLHCLETL DLRKTKIEIL
PAEIIGLPHL AHLFGKFKLG KDLKVGELEK KSLPKKCKLQ TLAGFVADEN PGFLQLMSHM
KKLKKVKIWC CESTDENNES MPHISEAVQK FAQDGMDTAD VRSLTLDFGN SSGGFLGSIQ
EYCYLSSLKL RGRLTQLPQF VTSLCGLTEL CLSSTNLVGN DLSNLCMMPC LLYLKLVEAD
LTGFIIKDRG FPSLLSLCLI MQMPVLPTIG AGALPRLVSL QLLCKDLVGL SGIKIEQHHC
LQEVALDSMV SAKTVDMWET AAKKHPRRPK VLFLKRIGPS ETKSTVKYVA ADEPIRDKAS
SVEFNQVQLT QNMLQDECMI SLDQSSSMSK LNSAMKKIIV SDPPPDTPEL SSSGNSVMPP
SASIC
//
