ID A0A3B6PMD2_WHEAT Unreviewed; 485 AA.
AC A0A3B6PMD2;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
GN ORFNames=CFC21_088344 {ECO:0000313|EMBL:KAF7084815.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6B02G246600.3};
RN [1] {ECO:0000313|EMBL:KAF7084815.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7084815.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6B02G246600.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6B02G246600.3};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6B02G246600.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7084815.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7084815.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
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DR EMBL; CM022227; KAF7084815.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6PMD2; -.
DR SMR; A0A3B6PMD2; -.
DR EnsemblPlants; TraesCS6B02G246600.3; TraesCS6B02G246600.3; TraesCS6B02G246600.
DR Gramene; TraesCS6B02G246600.3; TraesCS6B02G246600.3; TraesCS6B02G246600.
DR Gramene; TraesCS6B03G0724200.3; TraesCS6B03G0724200.3.CDS; TraesCS6B03G0724200.
DR Proteomes; UP000019116; Chromosome 6B.
DR Proteomes; UP000815260; Chromosome 6B.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 295..375
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 403..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 52987 MW; F1CD2303F293EA3F CRC64;
MASQQPSLAI LVREPDGFTV WPGPPYPPGS SPPQRLPKTA CSATSFSRDG SRLLATVASA
SATVYDCSSL SVIRSFDLPG LTAAALSPTG SYLQTFQKSS SPQVKNVTVW HVDTATALYQ
HYQKNLSKAN WPMVQFSADE SVACRMATNE MQFFDTNDFT KGIVYKVRLP GIAAMQLASA
PGSHVAGFVP EAKGVPASVQ IFSCDKDAQN QVVARRSFFR CSTVQFHWNK GSTGLLIVSQ
ADVDKTNQSY YGETKLHYLT TDRAFEGIVP LKKEGPVHDV QWSSSGSEFA VVYGFIVIAG
FGNLPGDMAF WDYSEKKLIQ KAKAEWSVIS EWSPDGRHFM TATTAPRLQI DNRIKIFDHT
GSLQFIKEFE KLYQVDWKPE SPERFGDIAE LTISLNGIKI EETKKQGQGS KSAQTSGKAP
VNVATKPAGA YRPPQSKHTA ALQDKLFGGL APTGGEMSKT ALRNKKRREK QKEKKAGEGS
SADDS
//
