ID A0A3B6PNB1_WHEAT Unreviewed; 984 AA.
AC A0A3B6PNB1;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=USP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_088194 {ECO:0000313|EMBL:KAF7084637.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS6B02G231700.4};
RN [1] {ECO:0000313|EMBL:KAF7084637.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7084637.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS6B02G231700.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS6B02G231700.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS6B02G231700.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7084637.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7084637.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; CM022227; KAF7084637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6PNB1; -.
DR SMR; A0A3B6PNB1; -.
DR STRING; 4565.A0A3B6PNB1; -.
DR EnsemblPlants; TraesCS6B02G231700.4; TraesCS6B02G231700.4; TraesCS6B02G231700.
DR Gramene; TraesCS6B02G231700.4; TraesCS6B02G231700.4; TraesCS6B02G231700.
DR Gramene; TraesCS6B03G0659400.4; TraesCS6B03G0659400.4.CDS; TraesCS6B03G0659400.
DR Proteomes; UP000019116; Chromosome 6B.
DR Proteomes; UP000815260; Chromosome 6B.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd02661; Peptidase_C19E; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF685; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..125
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
FT DOMAIN 448..754
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 311..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 109827 MW; E7DA570F6D413DAD CRC64;
MLQPREADVP ALFVVFIVLP VIAYFLLGRW HDSVSKKTRV GVLGQKAAEE AFKVETMACP
DVILPGPSLR PMPYLRSVPS LRSEYHECAT CRGPAKTRCS RCKSVRYCSG KCQIIHWRQG
HKQTCQQWHV NGGSNSGGLS PTESSEQMPF LTNLNSPLPG GDSHLHDMNF DTVSEPSFAT
TDSYILDTDL FLTDRSNMNE SNQSLLSRVN SASVASCEKS NYSVDEETNS SEILSANKFF
TLRFQVSNNS YGCLDEKNGN HDFTYPLNNT VQQPNNCAPE TTKCPKASIT VYEPDMGVYF
TSDMTSSCEG PYSSATESLQ RSKSSGKYSG RGNVIYMKPP YPPGKVASSQ KTQEVLASYQ
YNVHEKNTSC KNEQRSAKSS VSTSNNLQGC TGISKLGTSK VEVLKKPSKF LKTSLVGLIN
DNKRSKVLFR YEDLVKFFQY EVRGISPRGL FNCGNSCYAN AVLQCLMCTK PLMIHLLLRL
HSKDCCSKNW CLMCELEQYA STLRESGGPV SPSRILSNLR NIGCRLGGGS QEDAHEFLRH
LVMSMQAACL DGLGGEKQVE QSLQETTLIQ QMFGGRLKSK VKCLRCHHES ERYENIMDLT
LEIHGWVESL QDALTQFTAP EDLDGDNMYK CGRCCAYVKA RKQLSVHEVP NILTVVLKRF
QTGKYGKINK CVTFPDMLDM VPFVTGAGDH PPLYFLYAVV VHVDTENASF SGHYISYVKD
MQGTWLRIDD SEVKAVSLNQ VMSEGAYMLF YLRSFPRPPR IYIEKGLLPD PSSSYRHSSK
SSKGSSKQEQ KQTESLFTSD DQIRGIYDFR PEEEGYRQDQ HAKLRSQNLY HTDDAFADSV
STDFSDATSS EWSLFTSSDE SSFTTESTRD SFSVADYGDN AGLDPITSIF GPYYAPDHPL
GNFVSCTRLS PSNPQTRYFP ESMGFVSDSS LPTQPYGNVH RGRYPDRACA SSAEPLASAN
QRSLYGRYNH SRDGIVQTSG FCHM
//
