ID A0A3B6RA15_WHEAT Unreviewed; 870 AA.
AC A0A3B6RA15;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_094996 {ECO:0000313|EMBL:KAF7092519.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7A02G005600.1};
RN [1] {ECO:0000313|EMBL:KAF7092519.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7092519.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7A02G005600.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7A02G005600.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7A02G005600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7092519.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7092519.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022229; KAF7092519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6RA15; -.
DR STRING; 4565.A0A3B6RA15; -.
DR EnsemblPlants; TraesCS7A02G005600.1; TraesCS7A02G005600.1; TraesCS7A02G005600.
DR Gramene; TraesCS7A02G005600.1; TraesCS7A02G005600.1; TraesCS7A02G005600.
DR Gramene; TraesCS7A03G0012000.1; TraesCS7A03G0012000.1.CDS; TraesCS7A03G0012000.
DR Gramene; TraesKAR7A01G0002220.1; cds.TraesKAR7A01G0002220.1; TraesKAR7A01G0002220.
DR Gramene; TraesROB_scaffold_021094_01G000100.1; TraesROB_scaffold_021094_01G000100.1; TraesROB_scaffold_021094_01G000100.
DR Gramene; TraesWEE_scaffold_002258_01G000300.1; TraesWEE_scaffold_002258_01G000300.1; TraesWEE_scaffold_002258_01G000300.
DR OMA; PNRITHY; -.
DR Proteomes; UP000019116; Chromosome 7A.
DR Proteomes; UP000815260; Chromosome 7A.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1181; OS08G0235651 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 1..49
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 132..368
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 870 AA; 98784 MW; C67FAB9A76B2B569 CRC64;
MHAALRKVGD VPRDQLDEQV KLWANEVRDL SYRMEDTIDK FLVGVEGPEL DDKPYKLKQL
IKKMGDLFTK GKTRHVIAKE IKRIKARVQG AADRRDRYRV HEVVANPVGG TTVEPRLLAL
YKDRKELVGI DDSLNELTKK LSVGDGDVSK QLKILSVFGF GGLGKTTLAN AVYHKLKVQF
DCSAFVPVGR NPSMKKLLND ILFGIDKKMY LELDERQLID KLRVFLEDKR YLIVIDDIWD
KKTWELVKTA LVCNNCGSRI ITTTRILEVA TRAGEVYRLQ PLSRYLSEDL FDRILFGGTI
KRPNHLPAEV YDKILHKCGG VPLAIITIAS LLVNKPVELW SKVYTSIGFG HEENEEVENT
RKILLFSYYD LPYHLKTCLL YLSIYPEDHL IEKDSLIWKW FGEGFIHEEP GVGLFEIGER
YFNGLVNRSM IIPVETLDFG MEMHDGIITG CRVHDIMLDM ICLLSKEENF VTVLDSNEQY
TTLHCNAHRL GVHRRVQPLA STSTFHARSL DAMCNVELSP SHSCFEVLRV LALEGNNFSN
KCNHLDHVGK LVHLRHLRVA SMGICELPKE IGHLNFLLVL DLGGNRIRKL PESIGRLSQL
KCLNICKTNV EVPYWIGNLT SLEELCLQKI NMDSNFVTEL GKLTELRKLR ISEGLVIYDD
TALNSWAKSV AKVSKIQVID IGFVLVYRRS SHADNPWEQN VLPPQLCVLH MAYEEPGLVA
MINPRVLPNL SRLKLYLFSP ELEVFGCFRE LVTLELKMVS ALHHDTMGGA DAFPKLRVFK
TQATLGSFQE GDMPVLEFLR FSAVAQSNDD DVSFDFDFGS LGNLPLLQEV TVDLFVSADH
KKAEETAKNA IDMLPNRITH YIIPKSQASN
//
