ID A0A3B6RPM4_WHEAT Unreviewed; 868 AA.
AC A0A3B6RPM4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_081454 {ECO:0000313|EMBL:KAF7076851.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7A02G561700.1};
RN [1] {ECO:0000313|EMBL:KAF7076851.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7076851.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7A02G561700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7A02G561700.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7A02G561700.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7076851.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7076851.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022226; KAF7076851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6RPM4; -.
DR STRING; 4565.A0A3B6RPM4; -.
DR PaxDb; 4565-Traes_7AL_D8899E7E8-1; -.
DR EnsemblPlants; TraesCS7A02G561700.1; TraesCS7A02G561700.1; TraesCS7A02G561700.
DR Gramene; TraesCS7A02G561700.1; TraesCS7A02G561700.1; TraesCS7A02G561700.
DR Gramene; TraesCS7A03G1369500.1; TraesCS7A03G1369500.1.CDS; TraesCS7A03G1369500.
DR Gramene; TraesPAR_scaffold_082531_01G000100.1; TraesPAR_scaffold_082531_01G000100.1; TraesPAR_scaffold_082531_01G000100.
DR OMA; LARSYWD; -.
DR Proteomes; UP000019116; Chromosome 7A.
DR Proteomes; UP000815260; Chromosome 6A.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF968; NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 5..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 174..397
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 868 AA; 98535 MW; 6FB99D5FA0CACFC7 CRC64;
MAESAVSIVL GNVNALAVRE TTMLCCVTLE VELLKDELKR LRGFLRDADN KWRRGDESTA
VLVGQIREVA YDADNAIEAA EYMQKRNRLK KGFMGTISRY ARLPSDLTNL HKVGVEIQRI
KRKISDIFES ANRLKIVDLG NTSTENLQVD GELPQEYGPM HQNFEDVVMV GFEDDYQEIV
GKLLDKGDSL SVVSLVAMGG AGKTTLARKF YTSTSAKQHF EIVSWVTVSQ KYKGIDLLKD
ILKQITGSTF RSADQMQEYE VAKMIHDFLS QKRYLVVLDD VWETDTWEIL NRTTRAFPDA
ENGSRILITT RKEDVANHVQ MPTHVHPLKK LDEQKSWELF SSKALPSYKR SVIHDVDEFE
KLGRKLARKC GGLPLELAVL GGYLSKNLNA QTWSDILLDW PSTKNEQMMR NMLARSYWDL
PNHYLRSCFL YIAAFPEDSM VYVSDLTQLW IAESFIPHIP NHTLEETAYK YVTELVERSL
VHAVETSMGG GRIAIIRIHD ILHDWCKEEA RQDGFLDGVD KTTGRAGAQL SSANLASYRS
TFQSLSNVIL PGAPNVRTLF GFQLESVSLP RLRFLRVLYI EGSTLRDFST VIGGCIHLRY
LKLHCCGGVM LPSSIGQLLY LQTIDLRDTK LDSQVPQSLW EIPTLRHVYL TDGFSPPPPA
RSVRQQHKEL QTLFWDVSDV GSECCYHDME ILLGQMGQLT TLFLVMSPMP SEVFNILAHM
PHLVDISLSN FGVLDKLPAE LPRGVKRLRL CAHVIKQDPM PILEKLHYLV VLDLSGYEGQ
TMFCSAQGFP RLQELKLVGF STDDWRIEVG AMPKLSDLTL RECNRKLPEG FLHLPSLNHL
MLYRMPQISE DDNTLKELER KGCQVESL
//
