ID A0A3B6RT96_WHEAT Unreviewed; 1183 AA.
AC A0A3B6RT96;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_100841 {ECO:0000313|EMBL:KAF7099167.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7A02G562800.1};
RN [1] {ECO:0000313|EMBL:KAF7099167.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7099167.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7A02G562800.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7A02G562800.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7A02G562800.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7099167.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7099167.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022229; KAF7099167.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6RT96; -.
DR EnsemblPlants; TraesCS7A02G562800.1; TraesCS7A02G562800.1; TraesCS7A02G562800.
DR Gramene; TraesCS7A02G562800.1; TraesCS7A02G562800.1; TraesCS7A02G562800.
DR Gramene; TraesCS7A03G1372400.1; TraesCS7A03G1372400.1.CDS; TraesCS7A03G1372400.
DR Proteomes; UP000019116; Chromosome 7A.
DR Proteomes; UP000815260; Chromosome 7A.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1135; OS08G0246300 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 12..88
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 192..366
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 411..623
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 1183 AA; 133191 MW; 0D86074E8E5695D3 CRC64;
MAELVVGLSK SVVEGALTKV QSAIEDDAKL RQRAQRDLVS ITLEFEMMQS FLNVANEESV
KNTLVGTWVK HVRELAYDLE DCVENVVHLD SKPIFWRRLF QPCMALADCS LPLDQAVEEL
AELKGRAEEL SKCYSRYSNI TDSAGSKLIM MQQEGASSAI ALDMLLKARD AAKGQKFLGD
LTQLITQEGR PSNDLQVISV WGSAGNQGAI SIMMKTYKDP EICHSYTHRA WVKLMHPFNP
HDFIRNLMAQ FFEHSFEEQG ETTICVQLLT KMDEATQSQA HLFKKFEQLV TQERYLVVLE
DLSNMVEWHA IRKFLPHREN GSCIIVSTQE SEIASLCIGH TYEILELKQF SAEHSICALF
NKGPQCDRDK GEETGVGKTA AQDWMTKHPL VGRESEMNNL RQYTSKARFY SFEVMSVWGI
AGVGKSALLK NLLCDTVLND CRLVEKTKPS IFDKYAWVDV SYPFNLREFS RSLLLSFHSQ
SLQANKDHDI DMMGSKNPIL ECRGILKQVR CLVVIDGIES TKEWDLIQAE LVSGSSKNCI
IIITAEESVA RHCRGNKGEL TFNVKGLQAD DALALFKEEV TRKNKSFPSK YHDPDLEVQL
HELTLKCGGL PKVIIAIAGL LAPLKPDTFK DTVRYLNDGF MDHIETNREF DCLSGLFGWM
NSIILNPPDF LKPCIFYLAI FPPNQIIRRR RLIRRWIAEG YSRVLLEKHG EENAEKFFSQ
LLEKSIFQQV TQLSGTTLND TRMSFYQVNG LIREYIVSRR MEENLVFELG GRSSVLTSQS
TGRHLVISSR DTEKTVFESI DFSRLRSLTV FGQWESFFIS KSMKMLRVLD LEDASGSVEY
EDLKKMVKLL RRLKFLSLRG RPEINRLPSS LDHLRQLQTL DVRGTSTLTL PENITKLQKL
QYIRAGSTDV PATTPSPNVS SSWLCKRHSL VGVKVPGGLG KLTALHTLGV INVAASGSKT
FVKDLKKLTQ LSKLGVSGIN KKNSKEFFSA IEGHVHLESL SVQLDNETQG CCSRNRGNQG
CLDGIPMPLA LENLRSLKLY GLNDKLPEWG INQLSKLTKL DLEMATLMGN DMMKFLGELQ
QLCILRVKQL QDGTICFHVS VNNVVVHLFE KVKILQIACG SSSSSLHVSF GYKSMKKLEL
LKVDCHGGSP PYKLSGLENL KGLSRLLSAQ QDAACSLVYR NAI
//
