ID A0A3B6SIH6_WHEAT Unreviewed; 1021 AA.
AC A0A3B6SIH6;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Retinoblastoma-related protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_102653 {ECO:0000313|EMBL:KAF7101280.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7B02G162700.4};
RN [1] {ECO:0000313|EMBL:KAF7101280.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7101280.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7B02G162700.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7B02G162700.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7B02G162700.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7101280.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7101280.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication.
CC {ECO:0000256|ARBA:ARBA00025018}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; CM022230; KAF7101280.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6SIH6; -.
DR STRING; 4565.A0A3B6SIH6; -.
DR EnsemblPlants; TraesCS7B02G162700.4; TraesCS7B02G162700.4; TraesCS7B02G162700.
DR Gramene; TraesCS7B02G162700.4; TraesCS7B02G162700.4; TraesCS7B02G162700.
DR Gramene; TraesCS7B03G0441100.3; TraesCS7B03G0441100.3.CDS; TraesCS7B03G0441100.
DR Gramene; TraesKAR7B01G0158970.1; cds.TraesKAR7B01G0158970.1; TraesKAR7B01G0158970.
DR Proteomes; UP000019116; Chromosome 7B.
DR Proteomes; UP000815260; Chromosome 7B.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF17; RETINOBLASTOMA-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 103..248
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 433..633
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT REGION 878..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 112530 MW; 8C147E76D66D6266 CRC64;
MDGADAPQPA RSGSGVTACS TSTALGRMNG GANASNNAAA AMEERFADVC KRKLVLDEST
TRQAMQLFKE TKIILLSSMS SLGSGSPEEI ERSWCACVLY CVSKLGNAGK AKEDRGITLR
QILRAFDLKI VDFFKEMPQF CIKVGFILTG LYGSDWEKRL ELQELQANLV HLCSLGRHYR
RAYQELFLLN DGKPANNSSE LNVQQASEYY DFGWLLFLVL RNQASSAVKN LLTSTTELVS
VLAVLIIHIP VRLRNFSIED SSCFAKKSDK GVNLIASLCE RYLTSEDELS KALQKTNILI
KDILKKKPCS DVSECQQGSL SFIDPEGLTF FKNFLEEDSL KSSLQVLEKE YVNGLDTKGE
LDARMFANDE DSLLGSGSLS GGALKLPGTK RKYDDVMASP TKSTASRAPM SPPRFCPSPN
GNSFCNSKMA PFTPVSTAMT TAKWLRSTIS PLPSKPSGEL LRFFSACDKD VTDDIICRAA
IILGAIFTGS SFGERMCTSL RNTSGMDAIW TEQRKMEALK LYYRVLESMC RAESQILSGS
NLTSLLSNER FHRCMIACSA ELVLATHKTV TMMFPAVLEK TGITAFDLSK VIESFVRHED
SLPRELKRHL NSLEERLLES MAWEKGSSMY NSLIVARPTL SAEINRLGLL AEPMPSLDAI
AVHHDISLGG LPPLPFHKQP DKDEVRSPKR ACTERRNVLV DNSFRSPVKD VIKSKFLPPL
QSAFASPTRP NPAAGGETCA ETGIGVFLSK ITKLAAIRIK CLCERLQLSQ QILERVYSLV
QQIISQQTAL FFNRHIDQII LCCIYGVAKI SQLALTFKEI IFSYRKQSQC KPQVFRSVYV
NWPSRSRSGK IGEDHVDIIT FYNEVFIPTV KPLLVDLGPG TSPNRNNEPK SGGDAAPFPE
SPRLSRFPNL PDMSPKKVSA THNVYVSPLR SSKMDTLLSP SSKSYYACVG ESTHAFQSPS
KDLNAINTRL NSGKKVNGRL NFDVVSDLVV ARSLSDQNGG SAAAMAVFGT KTPVKGEQQD
P
//
