ID A0A3B6SRU7_WHEAT Unreviewed; 582 AA.
AC A0A3B6SRU7;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=NADH:ubiquinone reductase (non-electrogenic) {ECO:0000256|ARBA:ARBA00012637};
DE EC=1.6.5.9 {ECO:0000256|ARBA:ARBA00012637};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7B02G348600.2};
RN [1] {ECO:0000313|EnsemblPlants:TraesCS7B02G348600.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7B02G348600.2};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7B02G348600.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + H(+) + NADH = a quinol + NAD(+);
CC Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000864};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + H(+) + NADH = a ubiquinol + NAD(+);
CC Xref=Rhea:RHEA:23152, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC Evidence={ECO:0000256|ARBA:ARBA00000891};
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004137}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004137}; Intermembrane side
CC {ECO:0000256|ARBA:ARBA00004137}. Peroxisome
CC {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the NADH dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00005272}.
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DR AlphaFoldDB; A0A3B6SRU7; -.
DR EnsemblPlants; TraesCS7B02G348600.2; TraesCS7B02G348600.2; TraesCS7B02G348600.
DR Gramene; TraesCS7B02G348600.2; TraesCS7B02G348600.2; TraesCS7B02G348600.
DR Gramene; TraesCS7B03G0934500.2; TraesCS7B03G0934500.2.CDS; TraesCS7B03G0934500.
DR Proteomes; UP000019116; Chromosome 7B.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006116; P:NADH oxidation; IEA:InterPro.
DR Gene3D; 3.50.50.100; -; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR045024; NDH-2.
DR PANTHER; PTHR43706; NADH DEHYDROGENASE; 1.
DR PANTHER; PTHR43706:SF52; NADH:UBIQUINONE REDUCTASE (NON-ELECTROGENIC); 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 378..413
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 582 AA; 64669 MW; 9B93E2CE4E4B23F8 CRC64;
MGFSFFASRA AARFLEDIRR PAGVSTAALL LTAASGGGIV AYADSSRAEE APEPPPRKKK
VVVLGTGWAG TSFLKNLDSS RYEVKVISPR NYFAFTPLLP SVTCGTVEAR SVVEPIRRMF
EKKGKDVAYY EAECLKIDPT KKAVHCRSAV GTNLDGNGDF MLDYDYLVVA LGAAVNTFNT
PGVMEHCHFL KEVEDAQKIR KSVIDCFERA SIPNISEEEK RKILHFVIIG GGPTGVEFAA
ELHDFLVEDL VKLYPAIEQF VKITIIQSGE HILNTFDQRI AVFAESKFQR DGIELSTGFR
VIKVSDDSIT VKCKSSGVET LVPYGMAIWS AGIGTRPVIT DFMNQGKRRA LATNEWLRVP
ECDSVYAIGD CSSISQRKIM EDISTIFKVA DKDNSGTLTL KEINDVLEDI CIRYPQVELY
MKSMHMVDIA DLIKGGLGDS HKESMVVNIE EFKKALCHVD SQVKTVPATA QVAAQQGYYL
ADCFNKKDHC TEHPEGPLRL TGSGEGHHNF RPFRYKHLGQ FAPLGGEQAA AELPGDWVSM
GHSTQWLWYS VYASKQVSWR TRVLVVSDWT RRFIFGRDSS RI
//
