ID A0A3B6SU86_WHEAT Unreviewed; 991 AA.
AC A0A3B6SU86;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_105592 {ECO:0000313|EMBL:KAF7104718.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7B02G437300.3};
RN [1] {ECO:0000313|EMBL:KAF7104718.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7104718.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7B02G437300.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7B02G437300.3};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7B02G437300.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7104718.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7104718.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022230; KAF7104718.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6SU86; -.
DR EnsemblPlants; TraesCS7B02G437300.3; TraesCS7B02G437300.3; TraesCS7B02G437300.
DR Gramene; TraesCS7B02G437300.3; TraesCS7B02G437300.3; TraesCS7B02G437300.
DR Gramene; TraesCS7B03G1184500.2; TraesCS7B03G1184500.2.CDS; TraesCS7B03G1184500.
DR Proteomes; UP000019116; Chromosome 7B.
DR Proteomes; UP000815260; Chromosome 7B.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1089; OS02G0301800 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 13..94
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 171..408
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 991 AA; 111659 MW; 4BE1B40B4D86A4F3 CRC64;
MAAQAMVTAS TGAMNSVLSK LATLLEDECN PHTRNRIIAL RCALTSMRSF LERRAAASMK
DMDPLVEGWM KQVRDMTYDL EDCIDDFVCS DAPGNTNSVA QLIKVVTWRR QYTSLLQELK
EQVSGASERR WRYGVVCDPG DPLPIPSVVT NGLLPVFSAH VGCGLVGIEG SRDRLIKLLD
PDDKKQLKMV SIVGSRGIGK TTLAMDVYQS LKERFNCHTI VSVSSGDDLR IILTSILSQV
GVQEHDFREC DEEQLIHKLS ELLKTRRYFI VIEDIWDVSA WKIIRWAFPD NGCGSRILVT
TCISSIASPS CYFGKDDIFK MVPLSDTEAR KLFFMRIFHP EDCCPLHLKE NSFDILKKCG
GIPLAIITVA SLLATKSDEN EWKRVRDAIG SVFGKSATPE GMKQILHVAY FDLPVHLRTC
LLYLSIFPKG YVINKAQLIR RWMGEGFIIE EHVKSSEEVG ECYFSELVNR GLIQPVCIRY
DGRIESCQVQ NMIWDFILSK SSEENFVTRY DDRHGIFGLQ DRIRRLSLYC GRHEKDSFIL
SAITASHIRS LTIVVTDKEM PTLANFQALR VLDVESSGEL EDDNYLQKIG KPRLLKYLRL
QTKRFTELPE QVAELQFLQT LDLTSALISR LPHSIVRLKQ LIYLLVKNIK LPDEIGELQV
LQELSHVEVE SSNSPNSLEE LGRLSRLRVL GLNWCISDTD SSMEICADSL ISSLDKLGSS
NLQSLHIGTG SGCSLDFLLD SLSAPFNHLH EFRMTSDYYF PKIPGWMTTL VSLRVLEINI
DTVGEEALKI LGKLPSLLVL LLSVKSLAQN QGLTITSCGF RCLKQFDFIC SNVLDMVMFE
QGSMLALENL HLKFRVKGVF VNYGFQFDIE HIAALRYLRV DIACEDAEAR EMEVVEDAIR
SATSTHPGHP RLELRRLGEE DVMHGEGTDV ESEEMMEEDH TSPAVSCCPC NFYVADFHTH
LTDGCVNCRE LPTTIITLSG HICYIFGTSL S
//
