ID A0A3B6TI33_WHEAT Unreviewed; 1066 AA.
AC A0A3B6TI33;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CFC21_106507 {ECO:0000313|EMBL:KAF7105729.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7D02G018900.1};
RN [1] {ECO:0000313|EMBL:KAF7105729.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7105729.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7D02G018900.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7D02G018900.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7D02G018900.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7105729.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7105729.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022231; KAF7105729.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6TI33; -.
DR STRING; 4565.A0A3B6TI33; -.
DR EnsemblPlants; TraesCS7D02G018900.1; TraesCS7D02G018900.1; TraesCS7D02G018900.
DR Gramene; TraesCS7D02G018900.1; TraesCS7D02G018900.1; TraesCS7D02G018900.
DR Gramene; TraesCS7D03G0041600.1; TraesCS7D03G0041600.1.CDS; TraesCS7D03G0041600.
DR OMA; MENQYEA; -.
DR OrthoDB; 417588at2759; -.
DR Proteomes; UP000019116; Chromosome 7D.
DR Proteomes; UP000815260; Chromosome 7D.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1189; OS11G0462500 PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 14..96
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 189..411
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 943..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 119306 MW; 56F1FC77E9081302 CRC64;
MEAAAATAFA CRIAPKLLAF LATNHKLRQN LEHDITYIRN EFALISAAIQ QDDDHRWRSR
PSRDHMQRAW VKIIRDLAHA VEDCIDRFMH RVTISGTSTW LRQAVHRVQT VTVRKEFAKA
IREIKKISQE SSKLRETYYS ASIAAGTSSC SAASSSVASE TTTQMAIDDT LSAGRSVGMD
APQDELLELI QQQQQQLKVI SIVGFHGIGK TLLARRVYHR MENQYEARAW VSAAKQGVPT
NVLKQILQQL GIPTNGGGNF NKLCAVLRLY LGSKRFFIVI DDMQTEFWHD IKDIFVGLSG
RVLVTTAIQS VANACSSSAA HDHVYAMKTL ADEHSRLLFF KEAFQDDNPP VNKEDQLGSE
ALKKCDGLPL ALVTTARYLQ STGNPTRENW ATLCHNLGVH LETKEMLARM KCALVHSYTS
LVKHDVKTCL LYLGIYHTGR TVRRGNLIRK WCAEGFIQGD YMCNALDAAV ANFRELVNRS
IIQRTDASSK NIKDQVKTYR THGMMLEFIL HMSKCDNFIT LLYDQLAPPP PPSKVRWLSL
HDASARVAND LSLVRSLTVF GKAHESVLYF SKYELLRVLD LEECGNHLED KHLREICNNL
LLLRYLSLGA ALTVTVLPKE IKKLQLLETL DVRRTRIEIL PTQVMELPCL IHLFGKFKLQ
QGVGGRKMLK LQTWCSENSK LETVAGFVVD NNKSQGFAQL MEHMKHLTKV KIWCQQSTNN
SMDPISSGSS SSSKYTHLSE AIKGFIKRST DKKAHSLSLS FNDRWCQDLL VNLSLEKEQA
SSCYLSSLKV QGGNICSLPP FVTMLGGLTS LCLSSPHHQL SGDILAALSR VRCLAYLRLI
ASQLGKLVIV RGALGSLRRL CIVVEVMTEL EVQEGALPLL ESLQLLCKDL NGFCSIMIQS
LGRIKEVTLH DGVNDETRQK WKEAAKNHPR RPKLLFVKTA EDVDMGSEPA DNSESPTVPT
NDTTLPVTAP HDAISTGQSV QVDGDDLQQD DDEKEDTDKI DMLVDFVSKT CLGTMMNKES
FEQGMEGMVV GENRRKRART VGEGNSMDKV FDRVKRKNPE DIPVGL
//
