ID A0A3B6TR55_WHEAT Unreviewed; 324 AA.
AC A0A3B6TR55;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=spermidine synthase {ECO:0000256|ARBA:ARBA00012455};
DE EC=2.5.1.16 {ECO:0000256|ARBA:ARBA00012455};
GN ORFNames=CFC21_109086 {ECO:0000313|EMBL:KAF7108660.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7D02G266000.1};
RN [1] {ECO:0000313|EMBL:KAF7108660.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7108660.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7D02G266000.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7D02G266000.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7D02G266000.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7108660.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7108660.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) +
CC S-methyl-5'-thioadenosine + spermidine; Xref=Rhea:RHEA:12721,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443,
CC ChEBI:CHEBI:57834, ChEBI:CHEBI:326268; EC=2.5.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001199};
CC -!- PATHWAY: Amine and polyamine biosynthesis; spermidine biosynthesis;
CC spermidine from putrescine: step 1/1. {ECO:0000256|ARBA:ARBA00005123}.
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867, ECO:0000256|RuleBase:RU003836}.
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DR EMBL; CM022231; KAF7108660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6TR55; -.
DR SMR; A0A3B6TR55; -.
DR STRING; 4565.A0A3B6TR55; -.
DR EnsemblPlants; TraesCS7D02G266000.1; TraesCS7D02G266000.1; TraesCS7D02G266000.
DR Gramene; TraesCAD_scaffold_034386_01G000100.1; TraesCAD_scaffold_034386_01G000100.1; TraesCAD_scaffold_034386_01G000100.
DR Gramene; TraesCLE_scaffold_065978_01G000100.1; TraesCLE_scaffold_065978_01G000100.1; TraesCLE_scaffold_065978_01G000100.
DR Gramene; TraesCS7D02G266000.1; TraesCS7D02G266000.1; TraesCS7D02G266000.
DR Gramene; TraesCS7D03G0602100.1; TraesCS7D03G0602100.1.CDS; TraesCS7D03G0602100.
DR Gramene; TraesKAR7D01G0182170.1; cds.TraesKAR7D01G0182170.1; TraesKAR7D01G0182170.
DR Gramene; TraesPAR_scaffold_078904_01G000100.1; TraesPAR_scaffold_078904_01G000100.1; TraesPAR_scaffold_078904_01G000100.
DR Gramene; TraesRN7A0100589600.1; TraesRN7A0100589600.1; TraesRN7A0100589600.
DR Gramene; TraesRN7D0100621600.1; TraesRN7D0100621600.1; TraesRN7D0100621600.
DR Gramene; TraesROB_scaffold_029119_01G000100.1; TraesROB_scaffold_029119_01G000100.1; TraesROB_scaffold_029119_01G000100.
DR Gramene; TraesWEE_scaffold_052283_01G000100.1; TraesWEE_scaffold_052283_01G000100.1; TraesWEE_scaffold_052283_01G000100.
DR OMA; NVWFTDK; -.
DR OrthoDB; 1126121at2759; -.
DR Proteomes; UP000019116; Chromosome 7D.
DR Proteomes; UP000815260; Chromosome 7D.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004766; F:spermidine synthase activity; IBA:GO_Central.
DR GO; GO:0008295; P:spermidine biosynthetic process; IBA:GO_Central.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR030373; PABS_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR030668; Spermi_synthase_euk.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR NCBIfam; TIGR00417; speE; 1.
DR PANTHER; PTHR11558:SF11; SPERMIDINE SYNTHASE; 1.
DR PANTHER; PTHR11558; SPERMIDINE/SPERMINE SYNTHASE; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR PIRSF; PIRSF000502; Spermidine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01330; PABS_1; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 33..270
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 189
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 324 AA; 35469 MW; A0422A7F8357E960 CRC64;
MEAETAAKRA RENEGAAAAD GAGEQAGISA VIPGWFSEIS PMWPGEAHSL KVEKVLFQGK
SDYQDVLVFQ SSTYGKVLVL DGVIQVTERD ECAYQEMITH LPLCSIKDPK KVLVIGGGDG
GVLREVSRHS SVEQIDICEI DKMVVDVSKQ FFPHLALGFE DPRVSLHIGD GVAFLKNAPE
GTYDAVIVDS SDPVGPAQEL FEKPFFQSVS RALRPGGVVC TQAESIWLHM HIIEDIVTNC
RQVFKGSVNY AWTTVPTYPS GVIGFMLCST EGPSVDFQHP VFSIEEDEYS TKSKGPLKFY
NSEFHTASFC LPSFARRVIE AKAN
//
