ID A0A3B6TWH4_WHEAT Unreviewed; 621 AA.
AC A0A3B6TWH4;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=CFC21_110897 {ECO:0000313|EMBL:KAF7110823.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS7D02G442100.1};
RN [1] {ECO:0000313|EMBL:KAF7110823.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7110823.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS7D02G442100.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS7D02G442100.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS7D02G442100.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7110823.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7110823.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR EMBL; CM022231; KAF7110823.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B6TWH4; -.
DR EnsemblPlants; TraesCS7D02G442100.1; TraesCS7D02G442100.1; TraesCS7D02G442100.
DR Gramene; TraesCAD_scaffold_005309_01G000300.1; TraesCAD_scaffold_005309_01G000300.1; TraesCAD_scaffold_005309_01G000300.
DR Gramene; TraesCLE_scaffold_051674_01G000100.1; TraesCLE_scaffold_051674_01G000100.1; TraesCLE_scaffold_051674_01G000100.
DR Gramene; TraesCS7D02G442100.1; TraesCS7D02G442100.1; TraesCS7D02G442100.
DR Gramene; TraesCS7D03G1047800.2; TraesCS7D03G1047800.2.CDS; TraesCS7D03G1047800.
DR Gramene; TraesPAR_scaffold_045144_01G000200.1; TraesPAR_scaffold_045144_01G000200.1; TraesPAR_scaffold_045144_01G000200.
DR Gramene; TraesROB_scaffold_015259_01G000100.1; TraesROB_scaffold_015259_01G000100.1; TraesROB_scaffold_015259_01G000100.
DR Gramene; TraesWEE_scaffold_051744_01G000100.1; TraesWEE_scaffold_051744_01G000100.1; TraesWEE_scaffold_051744_01G000100.
DR OMA; RFMYDRT; -.
DR OrthoDB; 49016at2759; -.
DR Proteomes; UP000019116; Chromosome 7D.
DR Proteomes; UP000815260; Chromosome 7D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 22..228
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 360..570
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 104..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 69150 MW; 8CA8AC2B222834E2 CRC64;
MEEEIRAEFE GSGFTIGGDS AQILSTLLTY CVNYKMSPAD LVSNWEVYYL NRQLDGLKVE
SSYLDGFLSH LQNEVKEKLI KEETDLHIYS SNDVDMLLSN THTDEEGLLG TPSTKQEKPH
GESSNSELTP LTTERPSSIR AAKTNGDRIT PFAQRVNKFT QHYVLNADNV ASLPSKDEVE
TSEDELIRRI PPSQKCTLQV QRSKPEPGCR FMYDRMEDRF NYLEDRIGRS GRLFSATGLY
GQPADATLAS EENMFAVGMV ICDGEGRLNE KSILLQGSVE HSRGQRVRLD LKDINQFSLF
PGQVVGIEGH NPSGHCFVAS KLIDSIPVSV DDQLPCAKKQ AVDHEGHQNS NTLSRVLSSV
IAAGPFTTTD NLLFEPLQEL LSYACRKQPQ LLILMGPFID SDHPEIKKGT SDQSFHDIFH
FEILRKLQDF TQYLGHNVRV ILVPSVRDAH HDAVFPQPAF DSHLPEDITQ QITCLSNPSL
FSSNEIQFGC CTVDILKQLS GDEISRKPPG GKAADRIGRL ATHIVKQQSY YPLYPPAAGV
PMDFSLAKEA LEIPSAPDVL LLPSDLAPSV KVLSVNEDTE EHKRFICVNP GRLSKGIGGG
TFVELYYNED TEKTKAFIMR I
//
