ID A0A3B6U619_WHEAT Unreviewed; 1435 AA.
AC A0A3B6U619;
DT 05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KAF7073281.1, ECO:0000313|EnsemblPlants:TraesCSU02G110800.4};
GN ORFNames=CFC21_078300 {ECO:0000313|EMBL:KAF7073281.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCSU02G110800.4};
RN [1] {ECO:0000313|EMBL:KAF7073281.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7073281.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCSU02G110800.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCSU02G110800.4};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCSU02G110800.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF7073281.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7073281.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM022225; KAF7073281.1; -; Genomic_DNA.
DR EnsemblPlants; TraesCSU02G110800.4; TraesCSU02G110800.4; TraesCSU02G110800.
DR Gramene; TraesCSU02G110800.4; TraesCSU02G110800.4; TraesCSU02G110800.
DR OrthoDB; 347969at2759; -.
DR Proteomes; UP000019116; Chromosome Un.
DR Proteomes; UP000815260; Chromosome 5D.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR027806; HARBI1_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1095; OS05G0250700 PROTEIN; 1.
DR Pfam; PF13359; DDE_Tnp_4; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116}.
FT DOMAIN 14..91
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 188..423
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 1203..1345
FT /note="DDE Tnp4"
FT /evidence="ECO:0000259|Pfam:PF13359"
FT REGION 149..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1401..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 162548 MW; 25CF849605042594 CRC64;
MAMILDAFAY YVQNMLTEMV KEEVHMLLGV GDDIDKMDVK LGDLKNFLAD ADRRNITDKS
VQEWVGQLKR AMYEAADILD VCQLKAMERG SSTVDVGCFN PLLFCMRNPS HAHDIATRIK
GLNKRLDTIK ERSAAFSFIN LGSYEDRSSK VHASHSGNTR RETSGEFDRS GIVGEKIEED
TRKLVEIMLT EKEGNANIMV VAIVGVGGIG KTTLAQKVFN DETVKAEFDN TIWLSINQDF
DRVELLRTII TLAGGKHCGE KALAVLQPIL TTALTGKKLL LVLDDVWSHE AWGDVLEIPL
ANTLVRGSRV LLTTRDERVA RGMKAVLPYH HVDKLKEEDA WSLLKKQIVS SVTDIHEIDM
LKDIGLQIVA KCDGLPLAIK VMGGLLCQKD NQHSDWKMVL DDSIWSVSGM PKELNHAVYL
SYEDLPSCIK QCFLCYSLLP KAAKFLREDI IGMWISEGFL HGPSDDLEEL GRKYYKELIQ
RNLIEPDSKY IDQLFCNMHD VVRSFAQFVA RDEALAAHSG ESNIVSKLCA RKFLRLSLES
KASGSDGLDW SSLQAQDTLR TLISVGHINM KPGNSLVHFP CLRTLHIESA HAALVESLHE
FKHLRYLSLE RSDIRRLPES IGKMKFLQYI SLRGCQQFVE LPHSIVNLGH LRYLNFQKTS
INGIPRGFRV LTNLRKVNGF PARVDGDWCS LEELGPLCRL KYLEIQGLEN VTASSFSAKA
KLVEKLHLTN LCLTCGSRLG DDGLIEEETQ QIEKVFDELC PPPSLNFLAI EGYFGRRHPK
WMMSSSDMPL KNLRILMAED LASCTQLPDG LCQLPYLEFL QIDRAPAIKR VGHEFLQSYH
HQNPHPSKAV ISFLRLHTMK LMGLVEWEEW KWEEQVQAFP ALTELILFEC NLNRLPPGLA
SQARALKVLS VQQVKGLISL ENIASLIELQ VIENFHLERI TNLPRLQKLT ITRCPKLKVL
EGVPALQRLM LEDDYMETLP EYMGSINPRR LELYCSLALL ASMAVAQSGL EWDKFSHIEH
VKAYAHEGDN PRKWYALYTT NPYNLETNVN SSALMYRGTL FSLEDAQTFE SVFKMTRRTF
RYICSLVSLE LNYMTCYTFA DGRELSLQDL VAIVLRRLYS SEPPETIGST VGVNESTVLL
VTESFVAVLC NRAKHHLLWP DSSRMYKIKS MFDKIHNMNN CCGVICTTRI PFGPNRDSEY
YCSVIMQVII DPEMRFTNIW LASTGSMNPF SILHNSSLFN ECQKGDLLNG NKLKVALDGS
EVGEYIIGDV EYPLLPWLLT PYKEEELSDS KVEFNRRHSA ATTCMLNNVL ARFKGTWKYL
QEETWWPVNP DTLSNIINAC CILHNIVIDM EDDAAMPSSE AEDWSYHQQV RQLANEDAVR
ARDMLSQFFL ARMSSELGVG TVDAEEDHEL AATGSGDENK EQEAETKSAE EERQC
//
