ID A0A3B7DD76_9ACTN Unreviewed; 628 AA.
AC A0A3B7DD76;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:AXT85774.1};
GN ORFNames=C6I20_11630 {ECO:0000313|EMBL:AXT85774.1};
OS Aeromicrobium sp. A1-2.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=2107713 {ECO:0000313|EMBL:AXT85774.1, ECO:0000313|Proteomes:UP000257855};
RN [1] {ECO:0000313|EMBL:AXT85774.1, ECO:0000313|Proteomes:UP000257855}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A1-2 {ECO:0000313|EMBL:AXT85774.1,
RC ECO:0000313|Proteomes:UP000257855};
RA Liao L., Chen B.;
RT "Complete genome of Aeromicrobium sp. A1-2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR EMBL; CP027482; AXT85774.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3B7DD76; -.
DR KEGG; aeb:C6I20_11630; -.
DR OrthoDB; 57886at2; -.
DR Proteomes; UP000257855; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001607; Znf_UBP.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02148; zf-UBP; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50271; ZF_UBP; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Reference proteome {ECO:0000313|Proteomes:UP000257855};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 54..73
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 173..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 350..371
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 544..628
FT /note="UBP-type"
FT /evidence="ECO:0000259|PROSITE:PS50271"
SQ SEQUENCE 628 AA; 67328 MW; 8FA37146EDFF23AA CRC64;
METALTLVTL LAIVVSVSAG AGRIGLPAPL VLIVVGLVCS YLPFVPEFEL TPEIVLVGLL
PPLLYAAAIR TSLIDIRTYR RPIALLSVGL VLFTTVGVGL VVWMLMDVPL AVALALGAVV
APPDAVAATA IARRVGLPRR VVTILEGESL VNDATAIVTL RTSIAAISGS VSVWQIGAGF
AVSAIGGVLI GLVVAVVIGK IRSHIHDDVT DVAVSLLTPW IAYLPAEAIH VPGLDSEPSG
VLAVVVAGVI LGHKSPRIQS ASSRLFERTN WTTISYVLEN SVFLLIGLQI RAIVSDLGDS
AMTATEITVA CAVVLVTVIL LRIVWVFPAT YLPLMVPRIA ATESRPDPRA AFLVAWTGMR
GVVTLAAVFL LPSDTPEREV LVLMAFVVTV GTLLIQGLSI PWLVRALKVP GPDPQEDHLQ
EATVLQSVTD AGMAYLDEEV TDDISEAIMH RLRERATDRT NAVWERLGGN ETPSAQYARI
RNQMIGRERE ELLRIRKLGT VDQSVLQLVM NSLDVEESIL DRAYDDEVSA ERQEDLRPST
DPAAACEHLA AACTVPTPTT PMGCEECLAE GVGWVHLRLC MECGHVGCCD STVGRHATKH
FQQSGHPVMR SFEAGEAWRW CFIDNANG
//
