ID A0A3D8HYS1_9HELI Unreviewed; 385 AA.
AC A0A3D8HYS1;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Methionine biosynthesis PLP-dependent protein {ECO:0000313|EMBL:RDU58002.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:RDU58002.1};
GN ORFNames=CQA42_03630 {ECO:0000313|EMBL:RDU58002.1};
OS Helicobacter sp. MIT 99-5507.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=152489 {ECO:0000313|EMBL:RDU58002.1, ECO:0000313|Proteomes:UP000256421};
RN [1] {ECO:0000313|EMBL:RDU58002.1, ECO:0000313|Proteomes:UP000256421}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 99-5507 {ECO:0000313|EMBL:RDU58002.1,
RC ECO:0000313|Proteomes:UP000256421};
RA Mannion A.J., Shen Z., Fox J.G.;
RT "Novel Campyloabacter and Helicobacter Species and Strains.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDU58002.1}.
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DR EMBL; NXLO01000002; RDU58002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8HYS1; -.
DR OrthoDB; 9805807at2; -.
DR Proteomes; UP000256421; Unassembled WGS sequence.
DR GO; GO:0016846; F:carbon-sulfur lyase activity; IEA:UniProt.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000256421};
KW Transferase {ECO:0000313|EMBL:RDU58002.1}.
FT MOD_RES 199
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 385 AA; 42532 MW; E7AD7B6CC3780F41 CRC64;
MKENLAFESL LIHAGKTTDS LTGAVNRPIY QTSTFKQKAL GEHLGYEYSR TKNPTREGVE
SLITALEGAK FGFAFASGMA ALATTLSLFK SGDEIIILSN VYGGTFRLID KVFSNFNIIY
RIFEEKDISK LEDFISNKTK AILYETPANP LLNVVSIEQI SSIAKKKGIL SIVDNTFMSP
YLQNPLKFGA DIVVHSATKY LGGHSDLVAG LVVCNDELLG ERLGFLQNSI GAVLAPNDSF
LLIRGIKTLA LRMQRHSENT LFLAEFLSKH EAVSKVYYPG LKSDENYTLH NKQAKSGGGM
LSFVLKKNYD YKTFFKSTNI ITLAESLGGV ESLLCHPASM THASIPREIR LKMGIEDELI
RLSVGIEDKE DLKADLNEAI QRAKL
//
