ID A0A3D8IEB6_9HELI Unreviewed; 316 AA.
AC A0A3D8IEB6;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Magnesium transport protein CorA {ECO:0000256|ARBA:ARBA00019439, ECO:0000256|RuleBase:RU362010};
GN Name=corA {ECO:0000256|RuleBase:RU362010,
GN ECO:0000313|EMBL:RDU62881.1};
GN ORFNames=CQA44_06180 {ECO:0000313|EMBL:RDU62881.1};
OS Helicobacter sp. MIT 14-3879.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=2040649 {ECO:0000313|EMBL:RDU62881.1, ECO:0000313|Proteomes:UP000256842};
RN [1] {ECO:0000313|EMBL:RDU62881.1, ECO:0000313|Proteomes:UP000256842}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 14-3879 {ECO:0000313|EMBL:RDU62881.1,
RC ECO:0000313|Proteomes:UP000256842};
RA Mannion A.J., Shen Z., Fox J.G.;
RT "Novel Campyloabacter and Helicobacter Species and Strains.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates influx of magnesium ions.
CC {ECO:0000256|RuleBase:RU362010}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827,
CC ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00034269};
CC -!- SUBUNIT: Homopentamer. In the absence of Mg(2+), interactions between
CC subunits are weakened, and dimers, trimers and tetramers can be
CC observed in vitro. {ECO:0000256|ARBA:ARBA00025941}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362010}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362010}.
CC -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC family. {ECO:0000256|ARBA:ARBA00009765, ECO:0000256|RuleBase:RU362010}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDU62881.1}.
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DR EMBL; NXLP01000008; RDU62881.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8IEB6; -.
DR OrthoDB; 9803416at2; -.
DR Proteomes; UP000256842; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR InterPro; IPR045861; CorA_cytoplasmic_dom.
DR InterPro; IPR045863; CorA_TM1_TM2.
DR InterPro; IPR004488; Mg/Co-transport_prot_CorA.
DR InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR NCBIfam; TIGR00383; corA; 1.
DR PANTHER; PTHR47685; MAGNESIUM TRANSPORT PROTEIN CORA; 1.
DR PANTHER; PTHR47685:SF1; MAGNESIUM TRANSPORT PROTEIN CORA; 1.
DR Pfam; PF01544; CorA; 1.
DR SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU362010};
KW Ion transport {ECO:0000256|RuleBase:RU362010};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362010};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362010};
KW Reference proteome {ECO:0000313|Proteomes:UP000256842};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362010};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362010}; Transport {ECO:0000256|RuleBase:RU362010}.
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362010"
SQ SEQUENCE 316 AA; 36755 MW; 246C250541DC5447 CRC64;
MVSIFAKQNS LVIKQTYNEG EDIASKSILW LDLLNPTIDE IAHISKIYDI EIPNKEEREE
IESSARYWED KDSITINTRF LIKLGEESLK DETITFLLCK NMLFTIRYSE FKIFDEIQQR
VLASPRYFED GFDLISKIFE VRVEKDADII ENFTRDIREL RKGVFENIYD YNEVLGYLSN
LQDVNTRLRD SLFDKRRALT ALLSSNKLDF DVKSSITTIV KDLNSLIDFC VANMNALDNI
HALFASQINI EQNKIIKIFT VVTVAMMPPT LIGTIYGMNF THMPELDFTY SYPIVLLVMI
ISTIIPIVYF KKKGWL
//
