ID A0A3D8IHN7_9HELI Unreviewed; 942 AA.
AC A0A3D8IHN7;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=CQA53_07730 {ECO:0000313|EMBL:RDU64633.1};
OS Helicobacter didelphidarum.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=2040648 {ECO:0000313|EMBL:RDU64633.1, ECO:0000313|Proteomes:UP000256379};
RN [1] {ECO:0000313|EMBL:RDU64633.1, ECO:0000313|Proteomes:UP000256379}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 17-337 {ECO:0000313|EMBL:RDU64633.1,
RC ECO:0000313|Proteomes:UP000256379};
RA Mannion A.J., Shen Z., Fox J.G.;
RT "Novel Campyloabacter and Helicobacter Species and Strains.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDU64633.1}.
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DR EMBL; NXLQ01000018; RDU64633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8IHN7; -.
DR OrthoDB; 9811557at2; -.
DR Proteomes; UP000256379; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2190; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000256379}.
FT DOMAIN 43..269
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 535..566
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 596..625
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 942 AA; 105346 MW; 32F09CDF17B948FC CRC64;
MHKPSLLNKD YHAFYTEAKE FLENRIFIDY LHRFALGGDA SCYRYIPQIA IKAHNEDEII
KILALSRKYQ LPLTFRAYGS SLSGQACSDS ILVITTFGWR DIEVSEKNIK LSCGVIGSEA
NDALKAMGKK IGPDPATITM ASIGGIVSNN SSGMCCGVKQ NSYQTIESLR VILGDGTILD
TSSKESVESF LATHADMAKS LLDLRSEILA DSELSTLIRR KYKIKNTTGY SLNALLDFDN
ITDILNHLFV GAEGTLGFIS SVVLQNVDDE KYKACALLFY PDMNSTAYAI QILAQNDDII
SSAEVMDYAS LKSVQGLEGL PSVIDEIHEG NACILIQTQS NDLSTLESNL VRIKDSLTHT
NLLFPALYSQ DESEYSAWWK IRKGLLPIAS SLREDGSSVI TEDVCFEIEK FGEGVKFLQY
LFEKYGFKDN GIIFGHALSG NVHFIITPNL NDAVQRENFE KLVEEMAQGV ANMGGSIKAE
HGTGRMVAPF VEIEWGKKAY QINRKIKQIF DKANLINPDV IITDNPTIHT QNLKEMTKVD
DFINKCMECG FCEKACPSNP LTLTPRQRIA VMREIQRLQN LGTQDAHELR DEMINEYVYV
GDETCAACSM CATLCPLEID TAKIALHLRQ KQQKGLKVAN KILHNMNTTL HFAKFGLKMA
SIFNPKFLHS ISSKFRAISP NLPYLPLNLP QANNYQFNDV VINTESSVVY FSTCINRAFA
PSQNLSMNAD SRNIQEVFES ICKKAKVNVI YPQNLSNMCC GKAFVNYPTL QEENKQKIIR
ELNIATNGGK IPIVLDHSAC SYHLIKLLMD SGLKIYDMPN YIYEVLHSKL QFHPKNENIA
LYSMCALKKN NVSLEPLAKL CINGEIVIDR ALFCCGFAGN KGFFTPELNR NALQGFKRFY
ANSKTRGISR GFGSSSTCEI GLNDNSEIYW QHIVYLVDEV TR
//
