ID A0A3D8IWX0_9HELI Unreviewed; 572 AA.
AC A0A3D8IWX0;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Pyruvate carboxylase subunit B {ECO:0000313|EMBL:RDU69456.1};
DE EC=4.1.1.3 {ECO:0000313|EMBL:VEJ24007.1};
DE EC=6.4.1.1 {ECO:0000313|EMBL:RDU69456.1};
DE EC=6.4.1.7 {ECO:0000313|EMBL:VEJ24007.1};
GN Name=pycB {ECO:0000313|EMBL:VEJ24007.1};
GN ORFNames=CQA62_02065 {ECO:0000313|EMBL:RDU69456.1}, NCTC13205_00131
GN {ECO:0000313|EMBL:VEJ24007.1};
OS Helicobacter cholecystus.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=45498 {ECO:0000313|EMBL:RDU69456.1, ECO:0000313|Proteomes:UP000257067};
RN [1] {ECO:0000313|EMBL:RDU69456.1, ECO:0000313|Proteomes:UP000257067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700242 {ECO:0000313|EMBL:RDU69456.1,
RC ECO:0000313|Proteomes:UP000257067};
RA Mannion A.J., Shen Z., Fox J.G.;
RT "Novel Campyloabacter and Helicobacter Species and Strains.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEJ24007.1, ECO:0000313|Proteomes:UP000272814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13205 {ECO:0000313|EMBL:VEJ24007.1,
RC ECO:0000313|Proteomes:UP000272814};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; NXLU01000002; RDU69456.1; -; Genomic_DNA.
DR EMBL; LR134518; VEJ24007.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8IWX0; -.
DR KEGG; hcl:NCTC13205_00131; -.
DR OrthoDB; 9769961at2; -.
DR Proteomes; UP000257067; Unassembled WGS sequence.
DR Proteomes; UP000272814; Chromosome 1.
DR GO; GO:0034029; F:2-oxoglutarate carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000313|EMBL:RDU69456.1}; Lyase {ECO:0000313|EMBL:VEJ24007.1};
KW Pyruvate {ECO:0000313|EMBL:RDU69456.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000257067}.
FT DOMAIN 4..264
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 497..572
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 572 AA; 63508 MW; 66C3D1C3B7E4F12E CRC64;
MKGIKITENS LRDGVQSLLA TRVSTQDMLE VARIFEPIGF HSVEVWGGAT YDACLRYLNE
DPFERLKLFK EIFVKTPLQM LLRGQNLVGY RHYSDDVLKE FIALSTQGGI DIFRIFDALN
DSSNLKLSIE EVRKNGAEAQ GAICYTTSPV HHLKFFISYA KELVELGCQS LAIKDMAGLL
RPYDAYELVK AIKEEVGVPL SVHIHATTGF AFGSMLKAIE AGADVLDLSN SALSGGTSHP
CTQALVATLQ GTQWDTGLSL EPMEEASKIL REIRAKYSEF ESSYNSVDTE ILLSQIPGGM
ISNLASQLKE QNALERMPEV AKEIIAVRED FGYIPLVTPT SQIVGTQAVL NVLQNHRYKT
LTTESKNLIL GLYGKTPAPI KEELVQKVSN QGLPQKPQNE LQKAQEESRE FAQSRTDVIS
YALFGDVAKN FLKGERKPIV PSPKTNLGHH FQAKLLRQDY KIEILEVQST QEGESVKLRI
DDEEKEVFFS ASNPKSGEYE ENEKAIYSPM GGTLSKIFVK EGDKITKDTV LGVVEAMKME
NEILSHQEGE IAQVCVESGS NIQSSTILFL LK
//
