ID A0A3D8IX28_9HELI Unreviewed; 399 AA.
AC A0A3D8IX28;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:RDU69465.1};
DE SubName: Full=Malate oxidoreductase {ECO:0000313|EMBL:VEJ24016.1};
DE EC=1.1.1.40 {ECO:0000313|EMBL:VEJ24016.1};
DE EC=1.1.5.4 {ECO:0000313|EMBL:VEJ24016.1};
GN Name=maeB {ECO:0000313|EMBL:VEJ24016.1};
GN ORFNames=CQA62_02110 {ECO:0000313|EMBL:RDU69465.1}, NCTC13205_00140
GN {ECO:0000313|EMBL:VEJ24016.1};
OS Helicobacter cholecystus.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=45498 {ECO:0000313|EMBL:RDU69465.1, ECO:0000313|Proteomes:UP000257067};
RN [1] {ECO:0000313|EMBL:RDU69465.1, ECO:0000313|Proteomes:UP000257067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700242 {ECO:0000313|EMBL:RDU69465.1,
RC ECO:0000313|Proteomes:UP000257067};
RA Mannion A.J., Shen Z., Fox J.G.;
RT "Novel Campyloabacter and Helicobacter Species and Strains.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEJ24016.1, ECO:0000313|Proteomes:UP000272814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13205 {ECO:0000313|EMBL:VEJ24016.1,
RC ECO:0000313|Proteomes:UP000272814};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; NXLU01000002; RDU69465.1; -; Genomic_DNA.
DR EMBL; LR134518; VEJ24016.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8IX28; -.
DR KEGG; hcl:NCTC13205_00140; -.
DR OrthoDB; 9805787at2; -.
DR Proteomes; UP000257067; Unassembled WGS sequence.
DR Proteomes; UP000272814; Chromosome 1.
DR GO; GO:0004473; F:malate dehydrogenase (decarboxylating) (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:UniProtKB-EC.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:VEJ24016.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000257067}.
FT DOMAIN 14..147
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 159..392
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
SQ SEQUENCE 399 AA; 43299 MW; 0FF6442460CCEF38 CRC64;
MSDLQKRAVD YHKGGKVGIS PKTKLESFTD LSLAYSPGVA YPCKEIEGNP LLAYELTSKG
NLVAVISNGS AVLGLGDIGA LASKPVMEGK SVLFKKFANI DSFDIEIDEK DPKKLISIIK
AIAPTFGGIN LEDIKAPECF EIEQTLKEEL DIPVMHDDQH GTAIVSSAAL LNACEIVKKD
LTELKVVIIG AGASAISCAK MYQSFGVKNI IMFDSNGVIH AGRDDLSQEK KIFISPTKYA
NYQEALKSAD VLLGLSRGNI LNQEDIKVMA KDPLIFTLSN PTPEIAPELI KEVRPDAIIA
TGRSDYPNQI NNVLAFPFIF RGALDVRAKA ISENMKKAAA MALAKLARQE VPLHLQELYG
RKLSFGKEYI IPVAFDERLL PLLSKAVAQS AIEDGLARI
//
