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Database: UniProt
Entry: A0A3D8IZ56_9HELI
LinkDB: A0A3D8IZ56_9HELI
Original site: A0A3D8IZ56_9HELI 
ID   A0A3D8IZ56_9HELI        Unreviewed;       968 AA.
AC   A0A3D8IZ56;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE            Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE            EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN   Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN   ECO:0000313|EMBL:RDU70185.1};
GN   ORFNames=CQA62_01245 {ECO:0000313|EMBL:RDU70185.1};
OS   Helicobacter cholecystus.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=45498 {ECO:0000313|EMBL:RDU70185.1, ECO:0000313|Proteomes:UP000257067};
RN   [1] {ECO:0000313|EMBL:RDU70185.1, ECO:0000313|Proteomes:UP000257067}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700242 {ECO:0000313|EMBL:RDU70185.1,
RC   ECO:0000313|Proteomes:UP000257067};
RA   Mannion A.J., Shen Z., Fox J.G.;
RT   "Novel Campyloabacter and Helicobacter Species and Strains.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00969}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDU70185.1}.
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DR   EMBL; NXLU01000001; RDU70185.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3D8IZ56; -.
DR   OrthoDB; 9804325at2; -.
DR   Proteomes; UP000257067; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.10.170; -; 1.
DR   Gene3D; 3.40.50.11180; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR   Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR   HAMAP; MF_00969; TRCF; 1.
DR   InterPro; IPR003711; CarD-like/TRCF_RID.
DR   InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR004576; Mfd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR037235; TRCF-like_C_D7.
DR   InterPro; IPR005118; TRCF_C.
DR   InterPro; IPR041471; UvrB_inter.
DR   NCBIfam; TIGR00580; mfd; 1.
DR   PANTHER; PTHR30580; PRIMOSOMAL PROTEIN N; 1.
DR   PANTHER; PTHR30580:SF0; PRIMOSOMAL PROTEIN N; 1.
DR   Pfam; PF02559; CarD_TRCF_RID; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF03461; TRCF; 1.
DR   Pfam; PF17757; UvrB_inter; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00982; TRCF; 1.
DR   SUPFAM; SSF141259; CarD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   SUPFAM; SSF143517; TRCF domain-like; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00969};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000257067}.
FT   DOMAIN          472..629
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          650..802
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   968 AA;  109519 MW;  F651576B911F6EA6 CRC64;
     MAFETLDYLS PQSQIKPFLL PELRIVFGDD LRSYFQELSA LSHTLRNYYA FEGKKILIAP
     ILSVMYALPS AQHLQSFWIQ KEQNYSIQEL KEKLSLYGYE FVDFVETEGE VSIRGDIMDI
     FIPHHPNPYR ISFFDVFVEE IKEFELESQL CLEGEVQSIE ITPPFFSLSE DEEKTIQETI
     QKQDFQSLSQ DVQGLGFWFL PHKILLPQVL STALTQEAKS EAIEFFSFQE QSDLGENDLE
     KCRVLEPIEG YSDILFDIKN LELLLAHQDK QITLLCNNSS VFENLKFHYN LEGVTLKTSP
     HIINILTPTE LILSLNTFSS KTKTKKPKIL LDELKIGEYI VHQDYGIGIF RGIVQTEIIG
     SVRDFIQIDY QGEDKLLLPV ENLHLIDRYI ANSGNVPILD RLGKGAFIKL RDKVKTKLFE
     IAQGIIALAA KRDLLEGCKI DITNPEIKVF QNACNFILTQ DQERSICEIF NDLCSGKVMD
     RLLSGDVGFG KTEVAMNAIF AVCKSGYQCA LIAPTTLLSS QHFASLQARF EGFNITLAKL
     DSTIKNKSAV LKNLAEGNIN VIVGTQALLN ATFKNLGLVV VDEEHKFGVK QKEKIKELSS
     NVHLLSMSAT PIPRTLNMAL SQIKGMSSLL TPPNEREGVR TFVKNYSDSL LKEAISRELR
     RGGQVFFIHN HIASIQKRKE KLLELMPSLK IALLHSQIQN SEEIMEDFFN KKYNLLLCTS
     IVESGIHLSN ANTMIVEGAD RFGIADLHQL RGRVGRGNKE GFCYFLIEDR ESLGEEAKKR
     LLALEQNSYL GSGASLAYHD LEIRGGGNLL GEAQSGHIKN IGYGLYLRML EECINALSGK
     EKLQAKSVEL KLNVSAYLNP ELIASDRLRL ELYRRLSLCK SVEEVFKIQA EIEDRFGKPD
     IYTKQFLDLI IIKILGSLCN LKMISNYGQN ITFLYNDGTK ETLKSASKDD DDVIAMILQT
     LRKKQKAL
//
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