ID A0A3D8JXA4_9BURK Unreviewed; 455 AA.
AC A0A3D8JXA4;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Multidrug transporter subunit MdtA {ECO:0000313|EMBL:RDU96991.1};
GN ORFNames=DWV00_20255 {ECO:0000313|EMBL:RDU96991.1};
OS Trinickia dinghuensis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Trinickia.
OX NCBI_TaxID=2291023 {ECO:0000313|EMBL:RDU96991.1, ECO:0000313|Proteomes:UP000256838};
RN [1] {ECO:0000313|EMBL:RDU96991.1, ECO:0000313|Proteomes:UP000256838}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DHOM06 {ECO:0000313|EMBL:RDU96991.1,
RC ECO:0000313|Proteomes:UP000256838};
RA Gao Z.-H., Qiu L.-H.;
RT "Paraburkholderia sp. DHOM06 isolated from forest soil.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDU96991.1}.
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DR EMBL; QRGA01000011; RDU96991.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8JXA4; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000256838; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000256838};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..155
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 217..331
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 47815 MW; 267CEF672D35D993 CRC64;
MAEQENRPPS HENGKRRTAD AVPAQRQTST RPRVVIAVVV ILAAALLWWH PWSRTSGNGA
GPATTAGHAG RGGRGAFSNL PQPVHVATAT AGDMPIVLTA LGTVTPLATV TVKTQLSGTL
QSVNFKEGQL VKAGDVLAQI DPRPYQISLE NAEGVLAKDT ALLQTARLDL KRYKTLLAQD
SIASQQVDTQ ASLVKQYEGQ VQSDHASIDT YKLDLTYARI TAPVSGRVGL RQVDPGNYVT
PSDANGIVVI TQLQPISVIF TTSEDNLPAI LKQMHAGAKL STTAYDRNNT IPLETGYLDT
IDNQIDTSTG TVKLRAMFPN TGQMLFPNQF VNARLLIDTI HNAVIVPSSA VLNGANGTFA
YVVKPDNTVT VRQLKIGPVD GERTSIASGL ALGERVVSDG SDRLKEGAKI TVAPDAATVL
HPASGASAAH AAHASGASGA HAHRHKSASG TAGAQ
//
