ID   A0A3D8MYX6_9DELT        Unreviewed;       521 AA.
AC   A0A3D8MYX6;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=RCK N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51201};
GN   ORFNames=DV096_03005 {ECO:0000313|EMBL:RDV39556.1};
OS   Bradymonadaceae bacterium TMQ3.
OC   Bacteria; Deltaproteobacteria; Bradymonadales; Bradymonadaceae.
OX   NCBI_TaxID=2283320 {ECO:0000313|EMBL:RDV39556.1, ECO:0000313|Proteomes:UP000256871};
RN   [1] {ECO:0000313|EMBL:RDV39556.1, ECO:0000313|Proteomes:UP000256871}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TMQ3 {ECO:0000313|EMBL:RDV39556.1,
RC   ECO:0000313|Proteomes:UP000256871};
RA   Wang S.;
RT   "Lujinxingia celare sp. nov., isolated from a marine island.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDV39556.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; QRGZ01000001; RDV39556.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3D8MYX6; -.
DR   OrthoDB; 9781411at2; -.
DR   Proteomes; UP000256871; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR   PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        25..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        48..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          387..476
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51201"
SQ   SEQUENCE   521 AA;  55423 MW;  BD2AC24F32CB9F06 CRC64;
     MIEVAVIVFG AAVAYGLGRG LRIPVMPLLI VAGLLFSLTG LLDDREVVGA MLEMGLTFLV
     FTAGLEMAPS RVREQVGAVW RVGLTQFVLL GGLAMVVLWL GGQSVEESLY VALAVAASST
     LVVVRILRQR RQIFEPLGRM LIGVLLLQDV LIILGLVVVS GLPEGPVVVL QRVGGGALLM
     GLAALLYWQV VPRVIDRFED DDEIGLLVVV ATLFAMLGLA SLVGVPIIVG AFAAGLSLSS
     FPTNALVRGL IGPLIDFFMA LFFVALGAFL VVPSMEELRV GLGLIVLLWV VTPVVVVVVA
     ERAGFTTRGA VEAGLLLAQT SEFSLVVALQ GVASGQLSEG TLTIITLVTV VTIGLTPWIS
     GRRMVLWGMR LHPRPRAVEG GTDVEDHVVV IGLGVAGSKL MEKIKQAQMQ AVGLDYDPAE
     VSHLRERGYQ VVWGDADDPR ALEALNLSQA RAVMITTGKL AHVEQVAERV EKGTPVWVNL
     MDDSQVSACE AVGAHTVNYS RASSRQVMAW FEGLEASKST S
//