ID A0A3D8QGN3_9HELO Unreviewed; 1474 AA.
AC A0A3D8QGN3;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Protein SERAC1 {ECO:0000256|ARBA:ARBA00040991};
DE AltName: Full=Serine active site-containing protein 1 {ECO:0000256|ARBA:ARBA00041701};
GN ORFNames=BP6252_11957 {ECO:0000313|EMBL:RDW60574.1};
OS Coleophoma cylindrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Dermateaceae; Coleophoma.
OX NCBI_TaxID=1849047 {ECO:0000313|EMBL:RDW60574.1, ECO:0000313|Proteomes:UP000256645};
RN [1] {ECO:0000313|EMBL:RDW60574.1, ECO:0000313|Proteomes:UP000256645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BP6252 {ECO:0000313|EMBL:RDW60574.1,
RC ECO:0000313|Proteomes:UP000256645};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- FUNCTION: Plays an important role in the phosphatidylglycerol
CC remodeling that is essential for both mitochondrial function and
CC intracellular cholesterol trafficking. May catalyze the remodeling of
CC phosphatidylglycerol and be involved in the transacylation-acylation
CC reaction to produce phosphatidylglycerol-36:1. May be involved in
CC bis(monoacylglycerol)phosphate biosynthetic pathway.
CC {ECO:0000256|ARBA:ARBA00037251}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the SERAC1 family.
CC {ECO:0000256|ARBA:ARBA00038024}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDW60574.1}.
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DR EMBL; PDLM01000015; RDW60574.1; -; Genomic_DNA.
DR Proteomes; UP000256645; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004155; PBS_lyase_HEAT.
DR PANTHER; PTHR48182; PROTEIN SERAC1; 1.
DR PANTHER; PTHR48182:SF2; PROTEIN SERAC1; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF13646; HEAT_2; 4.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00567; EZ_HEAT; 9.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000256645};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1474
FT /note="Protein SERAC1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017776055"
FT DOMAIN 452..582
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 33..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 166096 MW; 0EE30E37AA9390EA CRC64;
MDLIIIILML ILLVAGLITV NFEHRKKNAN TRLATDPQAA SQQDHEPDQT LPPQRGVHLR
QVYPDKTKET ETDIDIIAIH GLDTKSPETW TWVDQKNPTI RVNWLEDRAM LPSTVDRVRI
FTCDWPADLL QPSKLIQMEF LELALRLSAG IQSRPPGPSS GASRDRPILF IASCLGGIML
IKALVDAGKQ DNPLRRATRG IIFLATPFQG TSFEEVATWA VPCMEAWALV QRREVTKLLA
SVKKLDLDAL VRNFTQLIKQ QDPPCEVFNF YEKRVTSLPS KIFPWLPTRL RQEKLLVDRV
SATLEMVPDP LPLDQPHVLM NKFKGPECTD YKLVVGQVQR ILGNIRDGSP LEQADVWIRE
KHYTEDRLKI DRLSGERLMM EQCYINLAIV EQPRVDAASS GEPGNQEISP TSSHSSLRAR
LRVETPAEDI QVELGTLFDP RKGPNGLIAQ PKRIMIRGRA GVGKTTLCKK IIHDFQQGAW
NDIFHRILWV PLRKLKTWNA DKYTLGQLFH HEYFPGSPNG KMLSEALWRD IDAGNGKKTL
FILDGLDEVA GTFDPETNKH QLLITLLNQP NVVITCRPHG ALVSNLHPVS LELETVGFYP
DQMNDYIEMA LQKRPRHEID EVQSFLKDHF LIQDLMRIPI QLDALCYTWD RDYRIDPQLQ
TMTAIYHAIE HNLWKKDVVR LGKKDRGDPV TSSQIQSSSA PNVERLVRDE ILFLEGLAFT
GIYSDVINFD IKQLEDIYET FKPENDFLLE KTLPNLSFLR TSDQSSEYKD QNYHFLHLTI
QEYFAARYFV RCWKSGKEII CLKLNTGRSF QKEYPATDYL QEQKHNVQYD IVWRFVTGLL
QGNGSDTQLP RFFYTIEKEP RDLLGPVHQR LIMHCLSEVV IQKEPPSFTP LRKQLEIRLS
QWVLFECNST GHGSQLAREI ELPEQVLNKI LPNESKDISG LQIKVLRSIA DRNKQPLSIV
RLANDSLTQS DVSLELKVVA LRILGNLYKG SSSNLGTIVA LLKNNEVYVR MAAVEALAKQ
PALSPELLET IVALLKDKDS SVRKAAVSAL AKQQALSLEL LEAIVALFKD KYSFVREAAV
NALAKQQALS PELLEAIVAL LKDNDMFVRM AAVDALAKQQ ALSLERLEAK VAHLKDNDMF
VRMAAVDALA KQPALSLEPL EAIVALLKDN DMFVRRAAVD ALAKQQALSP ELLEAIVALL
KDNDIFVRMA AVNALAKQPA LSPKFLEAIV AHLKDKDYSV RRVAVDALAK QPALSSELLE
AIVALLKDNK ASVRSAAVNA LAKQPALSPE LLEAIVALLK DNEESVREAA LYALAKQPAL
SPELLEAIVA LLKDNEESVR EAALYALAKQ PALSSELLEA IISLLKDNDM FVRRAAVDAL
AKQPGLSLEL VGKDIESFYR SWVERSLLGY TSWYIMDKVS YIDMLDSRLY LEGKQDQLRV
SIKEAQQHLC LKNGGLHGLW TYVSEDSSDS MSIA
//
