ID A0A3D8QVF5_9EURO Unreviewed; 824 AA.
AC A0A3D8QVF5;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=NAD-dependent epimerase/dehydratase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DSM5745_09582 {ECO:0000313|EMBL:RDW65843.1};
OS Aspergillus mulundensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1810919 {ECO:0000313|EMBL:RDW65843.1, ECO:0000313|Proteomes:UP000256690};
RN [1] {ECO:0000313|EMBL:RDW65843.1, ECO:0000313|Proteomes:UP000256690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5745 {ECO:0000313|EMBL:RDW65843.1,
RC ECO:0000313|Proteomes:UP000256690};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDW65843.1}.
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DR EMBL; PVWQ01000013; RDW65843.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8QVF5; -.
DR STRING; 1810919.A0A3D8QVF5; -.
DR OrthoDB; 1848657at2759; -.
DR Proteomes; UP000256690; Unassembled WGS sequence.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000256690}.
FT DOMAIN 8..134
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 472..727
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 824 AA; 90132 MW; 138C49FC14F40833 CRC64;
MSNYDLTLFG ATGYTGKLCA SFIAEHYPTS IRWCLAGRSE ARLRSLARSL QSRFPDRVQP
EIEVLNDLEE RSVAPLIGRT KVVINGVGPF HRFSSGIVGA CARVGSCYVD FTTETLWIKE
LIERFEDVAR ESGAILIPGI SPTAPADLIA WLIAKQIRER YSTGPEEIVA TGKLDIKAMS
AGSLTTVLDS LETWGPGWYI SGNSWVLSDP AQKPKPKPKP SLVSRLFGYR HVPILGPLST
SFTGPGNASM VHRSASQDPE LYGQNFHYEE YLPAAGLRSA CLIHLITKAA ILLISIPLVR
SMLRWFVDPT KSLPGQDELR RLESAEYRAV GFIAKKGQDK VPVVQASFVR QGALYEFTAL
LACVGAKVLL GERAGLERAG KGGFFTPSSL GMEYVEGLRE AGVKIRGYTR NSGLGGDTAS
MHETLLAQVY KVRLDALSFS LNLSESSDLS AFYLLSQLSP AMPLDISSEK LLITGVSGYI
GFKTLLIALG RGYTVRALVR KESHVLDLQN KSPTVIAPAL KSSQLEFAVV PDFLAPDAIF
NVLHGITAVI HLASPLAVQT TNYDDDIIQP AISMVTTFLE AATRVPSVKR VVITSSCVTL
IPFEWNMHPD TERVYTPNDL NPALDTTPSS PMEAYWLSKG LARRATHDFV TKNKPHFDVV
NLLAGVVVGP DDRLLPSSSN EQPASALLDG TRASVLAPAL TTDLSSPFPY VAVPVHVGDV
ARAHVDAVDC GKVRGGSEFI LASDTDNQAG KEVEWDRDVR GVARRYFGRE VERGVLPCRG
SLETIRWRLD ARETERVFGW RLTGFEETVR QLIAQYLELR GLEE
//
