ID A0A3D8RRY7_9EURO Unreviewed; 5458 AA.
AC A0A3D8RRY7;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=DSM5745_06849 {ECO:0000313|EMBL:RDW76857.1};
OS Aspergillus mulundensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1810919 {ECO:0000313|EMBL:RDW76857.1, ECO:0000313|Proteomes:UP000256690};
RN [1] {ECO:0000313|EMBL:RDW76857.1, ECO:0000313|Proteomes:UP000256690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5745 {ECO:0000313|EMBL:RDW76857.1,
RC ECO:0000313|Proteomes:UP000256690};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDW76857.1}.
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DR EMBL; PVWQ01000007; RDW76857.1; -; Genomic_DNA.
DR STRING; 1810919.A0A3D8RRY7; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000256690; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 5.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000256690}.
FT DOMAIN 566..642
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1651..1727
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2733..2809
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3850..3926
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4931..5007
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2804..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5458 AA; 600766 MW; 56CB76CED846A40A CRC64;
MTINDGYKEK EAPSVGAQKV PSQLALSKKD PPEAVEVCLH ELIRRQCAAR PNADAVCAWD
GEFTYEELQT HANHLASVLD SRGVEPEVFV PILFEKTRWV LVAMLGVLKA GGAFVLLDPS
LPQKRLASIC TKVHARCIVS SPKNAEMAAE LVPDIIILDD AWGADTTSNP VVIIPDRAEP
HHAAYIVFTS GSSGEPKGVV IEHRSISTSA MAGGKAENLN RSSRALQFSS YAFDACLAET
VIVLVHGGCV CIPSDHDRNY NLADAARGLR VNWAHLTPSV ARILAVDDIP LLETLILLGE
APRQEDLQKW YGHVRLFNGF GPSECSMVCS VHEYDSADDT PTTIGTPTGS RLWVVEEDDL
EILVAAGHVG ELLIEGPIVG RGYLDDAPKT AAAFVNSPEW LRSRSPTATG RLYRTGDLVR
YLGDGSLQYL GRSGTEVKIH GQRMDVLDIE YHMRQCLGDV VQDIAVDVIT PNDDHDAPLL
VAFVLLQDSD EWSSERRFET EFASAQLHLQ QQLPAYMIPA AFMVVETMPL SNSGKLDRRS
LRALGNSSTR RVLYQGRDLE TSTKRSPAGV VEATMCALWA DALHMSTEEI GLDDNFWSLG
GSSIRAMKLA GAARRLGYEI TMQDMWDNKS LRKMASALEA RLVAGNATDC KEDAIVPPYS
LVADADLLPS LRAQCPVQAP AEIEDIYPCT PLQEGMFSLS RRASPNFTIY QRYSLATGTD
LERFRRAWAA TIEANPILRT RIVQADDGHL YQVVVRGEPI AWDTWPAGDD LPSHWHSWAT
GQPLLRLALS VDTQRDMPYH NFALAMHHSL TDGWAIALVL EQVQAAYEGD TLDRRPFAPF
VKYTLASQTG ECVEFWREQL ADLHAMPFPK LPNPEYRSEP SEMIVHTIVH GRDRAATTAD
GVTLSTQLRL AWAVLVSQYT DSADLVFGIT VAGRGAQVHG VESTTGPTIA TIPMRVKLDW
ESSVDWHLNE LQEWAVRTMR YEQLGLQQIA QLGADGGTAC QFQSLLLVQA DADDYKAPEI
FGRLDGEQQG AASSYALVLD CQLLADSVRI TASYDPQVIP GEQVERLLDQ LEHTLRQILD
APHMTLGKLE TISPADMGIL QRWNGMLPAR LDACAHELIA RRSASQPDAF AVCAWDGEFT
YHELEVEAGR LASMLRVQGV RPNTFVPVYL EKSRWATVAM LAILKAGGAF IMLDPSNPVA
RLQEICREIS APLLVTSNSL AGAAEALGPS ILILDPESLA ETAGNAEING WSAPTPEDSM
YLVFTSGSTG KPRGVVISHT NWCSSSEARC RQMKLDRDTR LLQFASYSFD FSVEDNMLTL
VAGGCICVPS DHDRTSDLAG AITNFKANYA NLTPSVARIL RPSDVPTLRL LAFCGEPSTK
ADIQTWCSDS SHVELLNLYG PAECAVTATT QCYPSASGET NDIGRGCGAV TWVVDSQGYE
RLAPIGAVGE LVIEGPLVGQ GYLNEPEKTA AAFIPPPRWL SQFRQGPSRL YRTGDLVQYL
ADGSLRYVGR KDTQVKIRGQ RVELAEIEFH VRQCFPNATD VAVDIVRPAA GLGPALVSWV
VVPDQGDIDP GHTGWLGLQN SIFQEMVTRA RPQLEASVPI YMVPDVFIPV RAMPLTRTGK
VNRRQLRSWT EEMSTEALSS WRLGQTGHRR PPVTPRQQLI QGLYAQTLNL PTEEIGLDDH
FFRRGGDSIL AMKLVALARA VGLPLAVADV FSHPHLIDLA DAKFLPQLVA EQQVPEAFSL
LPSDMIREAI IAGVVAGGVV AEEQIEDIYP CTPMQDGLMA LSLQSPGNYV ATWRHELQSD
LNLDRLQYAF MATVAANPIL RTRLMHCHPH GTFQVVIRDE QVAIPVFATK QEWEGARKLR
MSEMGLNSRL WEAALITSGT APQLILTLHH ALYDDWSIPL LWDQVQAAYH APTEALRPCP
FSPFVQYIVQ SKGADQFWRS HLENVQAPAF PAFPSSTHIP RPDKVFRHPV PDLPVGNRDF
TLSMAINLAW AILLSHYTDS DEVVFGLTVN GRGAFLPGIE TVTGPTVTTV PLRVLLQPRK
SVEGQMKDLR VQVMEMTAYE QFGLQNIRGL SSDAAHACSF QTHIGVQLLQ SSPANLLVKH
TEDLSADLRT VSSYAFVLVC ELSDSNQAAI DIVASYDSLV VLPAQAQRMV EQFEHILRQI
LSQPSQKVGN ISAMSPQDMI QLDQWNAILP KSYDRCLHDL VFEHADRNPG QPAISAWDGQ
LSYGELKQAS LHLASLLRER GVEQGSIVTI CSEKSKWVIV SMLSVLSLGA VVSCIDPKYP
VDRVQDVLNQ TQPSLILVSP GLAESFDGYG GKYSVIALPN DIPWAIDLGW QTHWVRDATK
AAFIIFTSGS SGRPKGIVAT HRNFATSIRN HSPAMRLTSS KRVLHFASYA FDASLHEIFA
SLVNGICVCV PSEHDRMNAL APFLIEQNVD WASLTSSMLA TLDPQIVPSL RTVVACGEPL
TRHVVERWAP RVSLLNGYGP AECSVCVAVG RVIAEDWKTG VIGPMFGSVG WVTLPSDPRR
LSPLGAVGEL LIEGPVVTDG YLERPDLTAD AYIEPPAWLV AYRKGRPGRV YRSGDLVEIT
SDGWIRYVGR KDTQVKLRGQ RLELAEVEYH VRCCLDCVDV VVEKVELSGS NNEATLVAFI
MGSADQNGAY TDSSSLFDPP NAAFSHKTQL AEVALRDLIP SYMIPSLFLS LREFPQTAGG
KVDRRCLRHE VSALSSVEIQ VYRQTAVPMQ QRQPTTNLES IIQEVLADVL SRESSSLGID
TNFFHVGGDS IGAMHLVSQL SGYGIRTTVE AIFKNPTIAS LSASIESSAS TSEDETLPES
ESDHSDMPFQ LLSLTNDQYR LFMDRIVYPL QDMGFTVSDA YPTSSIQEGM LLSQAKDGSM
YHNRYMFTLQ PHENGSIDPM RVGQAWQAVV DKHPLLRTVF RESVHTDGTM DQIVLEPSPA
AMVNLKATLD DLFEEFAQYC PSPIPPTHPP NRLTILAAQN GSIGCLLEAS HALLDGISWQ
VLLRDLALAY KGQLEPTSCN AYHDYVAHIQ EQDLETARKF WAEYAVGLDP CMFPPIVPAV
QDKPTTAEFG RQQIRLDRTQ ELSLLAQKHE LTIASVFQVA WALTLGAYCR TEDVCFGYMT
SGRDAPIPGI QDAIGPFINL LLCRVNLGEK TCILDLLRRC QQEFARSLQF QYRSLAAITH
QLGIRDIFNS ILSVNKRIPR LEVAGSPWVL GEQDADGSTE YQVALTVDVG DEGLDIVLDY
HSEWLSAKGA TFVLDAFAKA VEGIIHDPTQ TPTKISLLGY SSEQLVHIWN STATTAVDRS
LADIVLEQCQ NRPDAAAVCS WDGDFTYYEI ERYSRALELV LRSTPGVGEG CIVPIYASKS
RWVPVAMLAV VRAGAAFVLF DVSHPASRLK EICASINAEV LLTLRQNSLE ARKLGCGLLC
VDEMDGVEKE TKIETETETE GPEPGHVTAA FDSGRPLYLI FTSGSTGKPK GAIISHRAFT
TSASAHSHAL HITAASRVLQ FSSFAFDVSI AEILTTLTVG GCVCIPSEQQ RTDALADAAA
YLQVNWASFT PSVARVLQPL DFPTLRTVIL IGEVVTAKEI RQWAPAVDLF VTYGPAECAV
YCAASEAPIT PESNGREFGR LVGCQGWVVD PADVNILLPI GATGELLVHG PIVGHGYHNE
PGLTARAFIE PPSWLPLNAT LSSKLYRTGD LVRLTEQGTY EFIQRKDHQV KLRGQRLELG
EVEYQLRAAL VDGLDAIAEL CITTDGAKML VAFIHLPETV LPDPDLPLKD ERLLGSATDR
FRQVALEAQN RLHEKLPGYM VPTLFLPLQT VPLTSSAKID RRRLREIICC LSTEEVQAIV
GAHDIQDRPQ PITHTESLIH KVWVQVLKRS PKQISREDNF FRLGGDSILA IQSIPIARSF
GLNISMSDIF KYPRLCDLAA ASRPVDGDAI LSIPPFSLLP EDIRSNDLLE HAARECGVLP
SEIEDIYPCT ALQEGLMTLS ERSPGECAVT FEYQLDADID MERFVSAWKA TVSANPILRT
RMVHVEGLRG TCQAVTRTTV RVLESEDLES HRARLKAYET SMTLGSNLVV LSIVRRKRER
PIFFLTIHHA LYDAWSLSVL WRQVHAAYHG QHLHLRPFNQ FIKHCMGHDD AAQFWRSELA
DLRSPVWPSL PAARHVPTVR STIQRAIHFE QTSTEFTVST LIQLAWAVVM SCYTDSEDIL
YGLTLNGRNA PLPGIEELSG PTFATIPFRT QLRLNETVRT SLARVQDKIT NLASFQQYGL
RNIRHLGAEA AQACRFQCHL GIQPQSDDAD SGLYRSASSA SKEHGAFSDS ALIIICHLNK
LDKSQISVEV NYDKSVTSQA SPERIVSQFA HILQQLPGSL DSPLSRLDLV GPEDRDQLHE
WNSSLPSPSL RPLQEAVLAF ATTTPTSPAI SAWDGEFSFS ELNQLSHELA RHLQREGVGY
GSIVPVCFYR SKWVVVAMLA VLLAGGACVP LDPDHPPERI RAILAQTRPD LALVCEETGT
ALDSCNVRSL RVPLNPAPLE PATLCPLPVV DTHDPAFIMF TSGTTGQPKG IILEHTNLRT
SILHHSRPCN IDRNTRCLHF CSYAFDVSLY EIFTVLANGA CVCIPSEQDR LNDLPGFIAR
HRVNTAYIAT SLLHRLLKPE LVPDLHTINV GGEPLTQDIV DTWADRVNLI NNYGPAETTP
CAVGKVRKQT WASGQIGPVV GGRGWVTVPS DPSRLAMVGA IGELLVEGPI VSRGYLNEPL
KTAESYLSSP PPWIAEFRGD KSPSRLYRTG DLVSYMPDGS IRFIGRKDTQ VKLRGQRVEL
AEVEHHVRLY FPEASEVIAE VVTHGVPDGG PSNLVAFICL PQTRINGEAE EEEGIFLVAD
AGFVKNAQDA MRRLAAALPA YMVPTVFLPL LRAPRTQSGK LDRGRLRDLA AAIPRERLQP
LCPQPPAVGA PAPTSDEEML IDLWAAALSI PREQIGPNDD FFHLGGDSVS AMVLVSVARR
QGVLFSVSDV FLNPVLAALA TKMQYLHDVV EEDNAPYQPG SLLDIEDVET FLTQNTDVLP
PGIHANQVED LLPTTEFQRT FLVGPGTGSY LRISVPRAVN GGQVFGVFDA WVRHHPMLRT
VFVRHNHRTL AVVLRDAHIM MCHLHDPTGD IESYADSICA NDYATGIGDG AVHVKAWLVT
PADEHAPRLL IIRTSHAQYD GHSLPLLVDD LVAGLQSRPL RIDVPPYPVY LRYRQRQQTD
QAVRFWQDYL QGARMLDIPD VIQPICSRDT GNHMIYGRRS IPMPTPPEGI TLASLVKASW
AIVLARTTEK RDIVFGHTLN GRDAPTPATH ELIGPCVTVS PMRVTFPSTI PVLELLHLVQ
TQYARAMPFA DIDFEHIRQH ATNWDASTQF NSVVTHQTNQ ANNAPRTSVL LAGEDCAWRM
VDHGVTPHLN LTTTPWQNTL TIQLSAPSSR LSVRRLEDLL GTFCNTLAEV ERGGTLVL
//
