ID A0A3D8SIV2_9EURO Unreviewed; 936 AA.
AC A0A3D8SIV2;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0000259|PROSITE:PS50255};
GN ORFNames=DSM5745_02753 {ECO:0000313|EMBL:RDW86111.1};
OS Aspergillus mulundensis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1810919 {ECO:0000313|EMBL:RDW86111.1, ECO:0000313|Proteomes:UP000256690};
RN [1] {ECO:0000313|EMBL:RDW86111.1, ECO:0000313|Proteomes:UP000256690}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 5745 {ECO:0000313|EMBL:RDW86111.1,
RC ECO:0000313|Proteomes:UP000256690};
RX PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA Xiong C., Yue Q., Zhang X.;
RT "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT and Morchella septimelata.";
RL IMA Fungus 9:199-223(2018).
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RDW86111.1}.
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DR EMBL; PVWQ01000003; RDW86111.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8SIV2; -.
DR STRING; 1810919.A0A3D8SIV2; -.
DR OrthoDB; 1430490at2759; -.
DR Proteomes; UP000256690; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR PANTHER; PTHR11820; ACYLPYRUVASE; 1.
DR PANTHER; PTHR11820:SF115; FUMARYLACETOACETATE HYDROLASE; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000256690}.
FT DOMAIN 89..169
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 30..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 101852 MW; 7A84A0103AD3D018 CRC64;
MGWLTLRRRA DNHISDAGII PVPISPGKTG AYSEHTEDIS TTTPTNIQSH PPSRPSTFLG
KTYTFHLNIP DTDLPYIPPS TLHQLEESWK SSNPSPTAQH STSPPESVPL WIVIDNIVYD
CTAFQHTHPG GSVVIRSFVG QDCSWQFWRF HGPSHLSEYG GRLRIGRTSG VANRFVEPPR
MAAKEIKPNG VGWRTCGVLP AAESESGHWG PPSVRSRSSW FEDGVAGRFL QYWVWWFGLV
GRLAVQESFE IVSEQQYHGH DFVYFVYTVQ HSAIPRSIRD DLIQERSLCP WPQRRSAEWS
AAKDGGSALE IGDMRGAASV HGRLPTYYNE GHGEELLRFA IKLNSIFIPK MAFNYCAYVD
PASGEDRIGS LDQQSSHIQP LAFTSGTRIT NLYQVIEAGE ANIINARADP LPLSSVKLLP
TISGRDILAV GKNYAEHAKE FNSSGFDSSD KVDQPTAPVI FTKRATSIIA HGEDVLLHPG
FTETPDYEGE IGVIIGKAGH KIPESEAMDY VWGYTIINDF TARERQRDHK QFYIGKSPDT
YCPIGPVAVP KERLPEKENI RLQTFVNGEK RQDATMDQLI FSIPNLVSTL SQGQTIQPGD
TIATGTPYGV GFGFRPMKFL KPGDEVKVSV TGLGCLVNTM AALDAPNPTL NRVQSSTSIP
RANLKTRSTN GLLKVGPKHL FYQFHGQKDG TPVIFIHGLG GSSSYFTPLF DKLAPTHALH
LTDLEGHGLS PTSALSSLTI TSLANDIRDV YTLATNSPKP ATVIAHSMGC LVALKLALDT
PDLVEKLILL GPPPSPLPEA GSTASFARAE TVRAQGMLAV VDAIVNAGLS AKTKSSNPLA
VTATKISLLS QDPEGYAKAC MALARSAEET LDVERIAAKT LILTGSADAV SPPALCERYG
GRIPGSEVVV LEDVAHWHLF EDVEGVRGAV FGFLGV
//
