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Database: UniProt
Entry: A0A3D8SWS4_9EURO
LinkDB: A0A3D8SWS4_9EURO
Original site: A0A3D8SWS4_9EURO 
ID   A0A3D8SWS4_9EURO        Unreviewed;       353 AA.
AC   A0A3D8SWS4;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=L-dopachrome isomerase {ECO:0000256|ARBA:ARBA00042730};
DE            EC=5.3.2.1 {ECO:0000256|ARBA:ARBA00039086};
DE            EC=5.3.3.12 {ECO:0000256|ARBA:ARBA00038932};
DE   AltName: Full=L-dopachrome tautomerase {ECO:0000256|ARBA:ARBA00041631};
DE   AltName: Full=Phenylpyruvate tautomerase {ECO:0000256|ARBA:ARBA00041912};
GN   ORFNames=DSM5745_02013 {ECO:0000313|EMBL:RDW90238.1};
OS   Aspergillus mulundensis.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1810919 {ECO:0000313|EMBL:RDW90238.1, ECO:0000313|Proteomes:UP000256690};
RN   [1] {ECO:0000313|EMBL:RDW90238.1, ECO:0000313|Proteomes:UP000256690}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 5745 {ECO:0000313|EMBL:RDW90238.1,
RC   ECO:0000313|Proteomes:UP000256690};
RX   PubMed=30018880; DOI=10.5598/imafungus.2018.09.01.13;
RA   Wingfield B.D., Bills G.F., Dong Y., Huang W., Nel W.J.,
RA   Swalarsk-Parry B.S., Vaghefi N., Wilken P.M., An Z., de Beer Z.W.,
RA   De Vos L., Chen L., Duong T.A., Gao Y., Hammerbacher A., Kikkert J.R.,
RA   Li Y., Li H., Li K., Li Q., Liu X., Ma X., Naidoo K., Pethybridge S.J.,
RA   Sun J., Steenkamp E.T., van der Nest M.A., van Wyk S., Wingfield M.J.,
RA   Xiong C., Yue Q., Zhang X.;
RT   "IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium,
RT   Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis
RT   basicola), Ceratocystis smalleyi, two Cercospora beticola strains,
RT   Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina,
RT   and Morchella septimelata.";
RL   IMA Fungus 9:199-223(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-phenylpyruvate = enol-phenylpyruvate; Xref=Rhea:RHEA:17097,
CC         ChEBI:CHEBI:16815, ChEBI:CHEBI:18005; EC=5.3.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00036735};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate;
CC         Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509;
CC         EC=5.3.3.12; Evidence={ECO:0000256|ARBA:ARBA00036823};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000256|ARBA:ARBA00005851}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RDW90238.1}.
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DR   EMBL; PVWQ01000002; RDW90238.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3D8SWS4; -.
DR   STRING; 1810919.A0A3D8SWS4; -.
DR   OrthoDB; 2718868at2759; -.
DR   Proteomes; UP000256690; Unassembled WGS sequence.
DR   Gene3D; 3.30.429.10; Macrophage Migration Inhibitory Factor; 1.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR014347; Tautomerase/MIF_sf.
DR   PANTHER; PTHR11954; D-DOPACHROME DECARBOXYLASE; 1.
DR   PANTHER; PTHR11954:SF6; MACROPHAGE MIGRATION INHIBITORY FACTOR; 1.
DR   Pfam; PF01187; MIF; 1.
DR   SUPFAM; SSF55331; Tautomerase/MIF; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Reference proteome {ECO:0000313|Proteomes:UP000256690};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   REGION          73..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..353
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   353 AA;  39238 MW;  67F5D177B8D15E57 CRC64;
     MPQRRRRIDL SLLRRRQILS SASSSELSPD VPVLQSPMSF HAMASQQVPE ATLKQSNKLN
     RAPVKPSMFF DDKEEEEDGP VSKTIIDDDK DGSAPRTAHK VIGEECPPKS HFLEESFNTR
     LPWASPIARI GQDSYIVIEV KVNTCVKDED AALSRITTRM AQIYQRSESF MFVSIQIVPS
     LRFGNSTMPA YSMKIFALPY LIAPITNLRS TILIQAALQD ILHIPPASGI ILYIPVAEEN
     MATNNTTMMG EIARLQDDRG RGREPRFFQS LSRTLSRRKK SSSGASAPLS VATTSSWAEE
     TKPAAISESE GATLSVDESL ARPGKSRPRT LRLFASRRTP EHSDHSTRSN PVE
//
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