ID A0A3D8YSW0_9BACL Unreviewed; 650 AA.
AC A0A3D8YSW0;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:REB05570.1};
GN ORFNames=DVB69_14985 {ECO:0000313|EMBL:REB05570.1};
OS Sporosarcina sp. BI001-red.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Sporosarcina.
OX NCBI_TaxID=2282866 {ECO:0000313|EMBL:REB05570.1, ECO:0000313|Proteomes:UP000256461};
RN [1] {ECO:0000313|EMBL:REB05570.1, ECO:0000313|Proteomes:UP000256461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BI001-red {ECO:0000313|EMBL:REB05570.1,
RC ECO:0000313|Proteomes:UP000256461};
RA Rajandas H., Sivachandran P., Mai C.W., Cheong K.W., Teh C.S.J.,
RA Lim E.S.H., Yap I.K.S., Convey P., Chong C.W.;
RT "Draft Genome of Sporosarcina subantarcticus.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC external protons. {ECO:0000256|RuleBase:RU366002}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REB05570.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QQAK01000015; REB05570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D8YSW0; -.
DR OrthoDB; 9809206at2; -.
DR Proteomes; UP000256461; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR NCBIfam; TIGR00831; a_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU366002};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU366002};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU366002};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW Reference proteome {ECO:0000313|Proteomes:UP000256461};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU366002};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU366002};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 55..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 84..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 216..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 239..256
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 308..332
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT TRANSMEM 386..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU366002"
FT DOMAIN 7..409
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 650 AA; 73289 MW; F1A77D529CE2F9A9 CRC64;
MVIFEVILLM LSAVFLSNIL NRFLPTIAIP LIQIVLGIVL AIPLTNHSLE LSPELFLLLF
IAPILFNDGV NVDKKAIWRE RKSILSLSLG LVFVTVGLLG AFIHLLLPSI PLAAAFALAA
ALAPTDAVAV SALAEKVKVP HKIMHTLEGE SLINDASGLV SFQFAVAALM TGTFSLFHAS
TTFIVISIGG ILLGAVLSFL KIALMRRIRE LGIENSTSFI LMEVLLPFLI FVIAEKVGVN
GILAVVSGGI VHSLSYKKLN VEIAQLNLLS KNTWSVITFS LNGIVFVLLG TQIPNILQAI
LNDQQHNIIT LLGYILAITT VLLGLRFLWI VLFNNFQKTS ELVSKRRIKD TFLYTVSGVR
GTITLVSVLS LPLFLSDGTP FAGRDLLLFI AAGVILLTLL LANFTLHFFA PKVEGTLYQH
DPEWEIVMLR QVKKELRKNR TSENKSAIGK VIRMYNDRIF SLSNLKEMNN SERKLRQLIM
DWQLENTREL VKRDRIRIQL AFPVLRRLNK RLYKITKEKK YRVNAFYSRL LKRHLQGMHL
TPLTSDQRKE QRMILLQSNG QFITEKLKSL EDGQFSAELI EAFLLNYERM GGYGLPREAA
HHLHEWIDFA LHTERSYIQT AFEKGDISRS EMRRYRENLL AIESSIQLQD
//
