ID A0A3D9I4C2_9BACL Unreviewed; 2126 AA.
AC A0A3D9I4C2;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:RED56618.1};
GN ORFNames=DFP95_11391 {ECO:0000313|EMBL:RED56618.1};
OS Cohnella lupini.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=1294267 {ECO:0000313|EMBL:RED56618.1, ECO:0000313|Proteomes:UP000256869};
RN [1] {ECO:0000313|EMBL:RED56618.1, ECO:0000313|Proteomes:UP000256869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 8236 {ECO:0000313|EMBL:RED56618.1,
RC ECO:0000313|Proteomes:UP000256869};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RED56618.1}.
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DR EMBL; QRDY01000013; RED56618.1; -; Genomic_DNA.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000256869; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.287.490; Helix hairpin bin; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 3.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000256869}.
FT DOMAIN 771..846
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1808..1883
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2126 AA; 238292 MW; 88FEF16AB121DDF6 CRC64;
MTDERIFPEA MTSSEYLSEK NFWLEQLAGN HAPSHFFENR AKANQSVEYG LYSIRFPKEL
SEKIMLVSNG SLLSTYILLL SGVTGLLSIY SDNEDILVGT PLFKTQKSNN NHLLALRTIV
DRQGSYRQLL NQVKQTVVEA DKHPNVSYEE IAKTIHLSEN DHGSKELNTV VLLENIQDEY
QGRDTVFSFK ATDRLVDLSV RFNASFIRME SIERLVKHLI AFMLEALGNP DSIVSAIDLL
SEADKQRILR DFNATEAEYP RDKTIHELFE AQVEKTPDNA AVIFERQQLT YRELNARANQ
LARVLREKGV QQDNLVGLMA ERSPEMIVGI LAILKAGGAY VPVDPAFPEE RVRYMLQDSG
AKLLLTQPKW VEMATAAGVA EFALLSEETW AREADTNLAA TNGPESLAYV IYTSGSTGLP
KGVMVEHASV VNLLTGLQTQ YPLKAEGRYL LKTTNTFDVS AAELFGWFFE GGTLVVLPEG
DEKEPKQMAN AIRRHGVTHI NFVPTMLRAF LTFVNEEELS NIPTLQYVFT AGEAVAADTV
QLFHERMPQA LLANLYGPTE ATVYATGITL HPNTLETNVP IGKPLQNTQT YIVGESGDVQ
PIGVPGELCI GGTGLSRGYL NRPELTAERF VPNPFVSGER MYKTGDLARW QPDGNIEYLG
RIDHQVKIRG YRIELGEIEA QLLQSGLARE AIVIARENAL GQNELCAYVV AENRLSVARL
RGALGEKLPS YMIPTHFMQL DKLPLLPNGK IDRKALPEPD GKLTTGIAYV APRTVTEQAL
AEIWQDVLGV ERVGIHDNFF DLGGHSLRAL TLLSRLHRRL GVEISLQTIF KHPTIEGLAE
AAVSGEESVH EAIQAVPEQP HYPISSAQKR MYLVSQLEEA GTSYNMPAAL LLEGKVDRRR
IELAMKLLIA HHESLRTSFE MIEGTIVQIV HRKIAFAMSV KQATKEEPER IVEAFIQPFD
LSAAPLLRTE LVELATEKHL LLFDMHHIVS DGVSMGVLME QFKALYAGEE LPELRIQYKD
YAAWQRELAK SESMRKQEAY WLKTFAADVP TLQLPTDYPR PAIRRFEGSR IRFALNQTLT
EKLKRLALET GSTLYMVLLA AYSVLLSKYS GQEDVVIGSP IAGRTHADVE RVLGMFVNTL
AMRSYPSGDK TFAAFLREVK GMALEAFEHQ EYPFEELVEK LDLTRDMSRN PLFDTMFVLQ
NTERATLALP DLHISSFETA HPVAKFDLAM EMADEGKEVV LHLEYSTALF KPETIVRMGN
HFSQLLQEIA SNPHIPLKDI AMLSKREKEQ IEIGFNGAEA QYPQDKTLHG LFEEQVLKTP
DGVAVIHGDR QLTYRELDSQ ANLLALELHA QGVGAEQVVA ICMERSLEMA VGLLGILKAG
GTYLPLDLSL PEERIRYMLE DSRARWIVTQ EHLAGTFNFG IQEIRIEDVL RHENEVDRQL
EPRRLPLNLA YVIYTSGTTG TPKGVLIEHR SIANSLQWRR EAYGLKERDV VLQLFSYAFD
AFLTSFFAPL LSGARVILLG ETDAKDAGAI CKAIKEQAVT HLICVPSLYQ VIKEQLPASD
AQSLRHVTLG GEAIPRRLIE ESMEKYPQAE LANEYGPTEN SVVSTAALRL NKDDEVTIGK
PVSGVQAYIV NAYLQPVPIG VAGELCVGGI GLARGYLNRP DLTEEKFVPN PFIPGERMYR
TGDLARWLPD GNIDYLGRID HQVKIRGYRI ELNEVEAQLL RIGGMKEAAV VTQDNKRGEQ
ELCAYVVTEN ELTVVQIRKA LSQTLPRYMI PTYIVLLEKL PLTPNGKLDR KALPAADGHL
YRETEYVAPR NEAEQTLATI WQNVLGVNPI GVYDNFFELG GNSLKMMQMV QQIHLRLNRE
LALSTVFTHS TIDQLAGQLL ILSSQSKANE WNLHLPDKLF CLPPVHGYGI AYSQFANALQ
DEAGVIAFDF IEEQDRIEQY VQKIASVQPE GPIRIVGYSA GGILGLELVK ALELQGREVS
DLILLDSFPP ERSAPTNREI EEWAAEYLND FLNVHAYLQS YRGELVNKLK SYRKYCDNLK
LDGPISADIH LIQAEIDKNE AYMKQTRNEK SNYWKTMTNG QFNKYAGAGI HQDMLTDSFV
QSNVDLIKPI LRPKEEANSL KEIWIP
//
