ID A0A3D9IWX4_9BACL Unreviewed; 666 AA.
AC A0A3D9IWX4;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:RED66330.1};
GN ORFNames=DFP95_101829 {ECO:0000313|EMBL:RED66330.1};
OS Cohnella lupini.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=1294267 {ECO:0000313|EMBL:RED66330.1, ECO:0000313|Proteomes:UP000256869};
RN [1] {ECO:0000313|EMBL:RED66330.1, ECO:0000313|Proteomes:UP000256869}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 8236 {ECO:0000313|EMBL:RED66330.1,
RC ECO:0000313|Proteomes:UP000256869};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RED66330.1}.
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DR EMBL; QRDY01000001; RED66330.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D9IWX4; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000256869; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000256869};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..259
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 312..651
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 666 AA; 74152 MW; 8ED398B019C42091 CRC64;
MSKIMTEKAQ KSELSNRRHF SFRLNVFFFV TFSLFSLLIV RLAYLQFVEG ETLRAKEHEN
GSKRIPIPPI RGNIYDSAGN AIAYSISTQS LYYTLDLKMK ADEGMALAAR IVDIFNKLGN
KSKKPLTVLG VFEDMDLKGR VNSAFQPRRI KSGLTQEEIA YFSEHRDEFE GIEVVEESIR
QYSNDKLAVQ LVGYLKKLSG AVGNIDKYKG INNEEIDETL KYLTTEQVGA DGLELMYQDE
LRGRNGFKEY PINKDSQIIG PMKLTKPIKG DNLYLTINNQ VQLIAQQAIT DQIREIRTAP
NEFQKDSHPI TGYAVAMEVK TGKVVAMASM PDYDPSLWQG GISEKDWESV QYFMSNGTIR
DVQPPYADDK ERSIHPSSFV NLGSTQKPLT VLVGLSEKLI TPNSTFLDPG YFAFGSKGYE
TEVSNASRAM NGLLTPTMAI AKSSNAFMAK MIGNALYLRD GPKGVDIWDG YMKQFGLGVI
TGSGLPNESK GKTNYYEEIK SGSSQSALVY ASFGQQAKYS TLQLAQYAAT LASHGKRMKP
QFVNEIKDTD GNLVQPYKSE VLNTIRFPDS YWKTIEDGMA LVNVQGFDDF DYHFYRKTGT
SQQDVGSRKK VENAVFIAYA PAEDPVLAVA VVVPDGGYGG YAAAPIARKI FDAYDSEIGL
MGTPRK
//
