ID A0A3D9SPM0_9ACTN Unreviewed; 231 AA.
AC A0A3D9SPM0;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=DFJ69_3333 {ECO:0000313|EMBL:REE97858.1};
OS Thermomonospora umbrina.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=111806 {ECO:0000313|EMBL:REE97858.1, ECO:0000313|Proteomes:UP000256661};
RN [1] {ECO:0000313|EMBL:REE97858.1, ECO:0000313|Proteomes:UP000256661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43927 {ECO:0000313|EMBL:REE97858.1,
RC ECO:0000313|Proteomes:UP000256661};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REE97858.1}.
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DR EMBL; QTTT01000001; REE97858.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D9SPM0; -.
DR OrthoDB; 9792284at2; -.
DR Proteomes; UP000256661; Unassembled WGS sequence.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:REE97858.1};
KW Protease {ECO:0000313|EMBL:REE97858.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000256661};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 28..228
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 231 AA; 24193 MW; F5A75CB4781BC39B CRC64;
MSKILFVMTG SDHWTLADGT EHPTGFWAEE VVVPYRAFKG AGHEIVVATP GGVVPTVDKA
SLSADANGGR VNADDMADTL AAMTELERPV RLAAVDPNDH AAVFYPGGHG PMEDLAVNAD
SGRLLTRTLT AGLPLGVVCH APAALLAAVG DDGANSFAGY RLTAFTNEEE TRAGFADKAK
WLLEDQLVEA GVDFRAGEPW QPHVVTDRNL VTGQNPASAA PLAIELLAKL G
//
