ID   A0A3D9SQ65_9ACTN        Unreviewed;       352 AA.
AC   A0A3D9SQ65;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:REE98089.1};
GN   ORFNames=DFJ69_3572 {ECO:0000313|EMBL:REE98089.1};
OS   Thermomonospora umbrina.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Thermomonospora.
OX   NCBI_TaxID=111806 {ECO:0000313|EMBL:REE98089.1, ECO:0000313|Proteomes:UP000256661};
RN   [1] {ECO:0000313|EMBL:REE98089.1, ECO:0000313|Proteomes:UP000256661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43927 {ECO:0000313|EMBL:REE98089.1,
RC   ECO:0000313|Proteomes:UP000256661};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:REE98089.1}.
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DR   EMBL; QTTT01000001; REE98089.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3D9SQ65; -.
DR   OrthoDB; 9779574at2; -.
DR   Proteomes; UP000256661; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000256661}.
FT   DOMAIN          15..340
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   352 AA;  38181 MW;  4A307C646EB5B8A5 CRC64;
     MEADPVFTRP IRTLPKAHLH LHFTGSMRHS TLVELAERHR VHLPDALVED WPPRLRATDE
     RGWFRFQRLY DIARSVLREP DDVRRLLREA AEDEAAEGSG WLEIQVDPSG YAGRFGGLTP
     TVELVLSAAE EAETATGVGI GIVIAANRTR HPLDAKTLAR LAAGYAGSRV VGFGLSNDER
     RGRAYDFEGA FRIARRAGLL STPHGGELRG PGSVRECLDV LRADRIGHGV RAVEDPALLD
     RIVERGVTLE VCPASNVSLG VARSAAEVPL RALFEAGARL ALGADDPLLF GSRLARQYEL
     ARTEHGFTDA ELATLARASI EGSAAPTNVR KQLLGDIDTW LTAPPTHAVT AA
//