ID A0A3D9SXL5_9ACTN Unreviewed; 1665 AA.
AC A0A3D9SXL5;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Lhr family ATP dependent helicase {ECO:0000313|EMBL:REE99250.1};
GN ORFNames=DFJ69_4758 {ECO:0000313|EMBL:REE99250.1};
OS Thermomonospora umbrina.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=111806 {ECO:0000313|EMBL:REE99250.1, ECO:0000313|Proteomes:UP000256661};
RN [1] {ECO:0000313|EMBL:REE99250.1, ECO:0000313|Proteomes:UP000256661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43927 {ECO:0000313|EMBL:REE99250.1,
RC ECO:0000313|Proteomes:UP000256661};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REE99250.1}.
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DR EMBL; QTTT01000001; REE99250.1; -; Genomic_DNA.
DR Proteomes; UP000256661; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17922; DEXHc_LHR-like; 1.
DR CDD; cd18796; SF2_C_LHR; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013701; DEAD/DEAH_assoc.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47962:SF5; ATP-DEPENDENT HELICASE LHR-RELATED; 1.
DR PANTHER; PTHR47962; ATP-DEPENDENT HELICASE LHR-RELATED-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08494; DEAD_assoc; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:REE99250.1};
KW Hydrolase {ECO:0000313|EMBL:REE99250.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000256661}.
FT DOMAIN 35..229
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 272..451
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 947..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1453..1539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 178573 MW; 221B4E3B9D1F9AD3 CRC64;
MGDVRDDVLE RFSPATRAWF TGAFATPTAA QAGAWESIAR GEHTLVVAPT GSGKTLAAFL
WSLDRLAVPP PQPLDREHRC RVLYISPLKA LAVDVERNLR APLTGIRQAA RRLGLPEPDV
RVGIRSGDTP TDERRRLVTR PPDILITTPE SLFLMLTSQA RETLRGVETV IVDEVHAVAG
TKRGAHLALS LERLDALLER PAQRVGLSAT VRPVDEVATF LGGSRPARVV QPPHDKRFEL
EIVVPLEDMT EVGQSFGGEE PAEPSRRSLW PHVEDRVLDL IESHRSTIVF ANSRRLAERL
CGRLNDLAYE RLHGGVLPES PVPAEMMAQA GAGRGAPQEV ARAHHGSVSK EERAGIEDAL
KQGRLPAVVA TSSLELGIDM GAVDLVVQVE SPPSVASGLQ RVGRAGHQVG AVSKGVIFPK
YRGDLVQTAV VAERMRDGDI EELRYPRNPL DVLAQQIVAM VSMDEWAVDE LETTVRRAAS
FATLPRSALE ATLDMLAGRY PSEEFGELRP RLVWDRVAGV LQGRPGAQRL AVTSGGTIPD
RGLFGVFLVG EKSSRVGELD EEMVYESRVG EVFVLGASSW RIEDITADRV LVSPAPGQPG
KLPFWHGDSP GRPAELGRAL GSFTRELSRM SPEEATERVR AAGLDAWASG NLVAYLAEQR
EATGYVPDDR TLVVERFRDE LGDWRLVVHS PFGARVHAPW ALAIAARLRE RYGVDAQAMH
ADDGIVLRIP DMDEPPRLDL ALFDADDLER IVVDELGASA LFAARFRECA SRSLLLPRRR
PDRRMPLWQQ RQRAAQLLSV AGKYGSFPIV LETMRECLQD VFDVPGLVQL MRDLAGRKTR
MVEVETQAPS PYARSLLFHY VGAFMYEGDA PLAERRAQAL ALDSALLAEL LGQADLRELL
DPEVVAETER ELQRLTADRR ARDVEGVADL LRILGPLSTD EVAARVTVGP SARDDPGLGP
DRLELQPAPV SPLRDSGRRG DRPPDGSGTG SDEGLSDGAR AEPDEGSPNE AGAGLSDGAQ
AAAVGWLGAL ERARRVIRVR VAGAERWAAI EDAGRLRDAL GAPLPVGVPE AFLEPVDDPL
GDLVWRYART HGPFRVGDLA ARFGLGIAVV TETLRRQSAA GRVVEGEFLP VESLSGPPTG
EWCETGVLRM LRRRCLARLR AEVEPSPPEA LGRFLPAWHG ISAGRLRGMD ALVQAIEQIQ
GAAVPASALE PLILASRVPG YSPALLDELT SAGEVVWAGQ GGLPGGDGWV ALYLADTAPL
LMPEPAEITM TPVHEAALAA LADGGALFFR TLSDRVNAAG VQAGDQDLVS ALWDLVWAGH
LTNDTLAPLR AALGSGRPAH RPRTSRRGRP VLPSRTGPPT VAGRWWPLPG RESDTTRRSH
ALAEALLERH GIVIRGAVAA ERTPGGFAAV YPVLRAFEDT GRCRRGYFVE GLGAAQFALP
GAVDRLRALR EPSSSLPMGS GFVRGPSPEN DPWTTSPPPA VESGPEAAWQ GTSPATGSRN
APLEGSPGVG TAARDGGPRS VSRGGPGASP WATPGASAPT RPRALVLAAA DPANPYGAAL
PWPERDTEAA SSHKPGRKAG ALVVLVDGVL TLYVERGGRT LLTWADDPTT LQPAVDALAL
AVREGVLGKL TVERADGESI GSSPLAEALE AAGFHPTPRG LRLRA
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