ID A0A3D9SYS1_9ACTN Unreviewed; 705 AA.
AC A0A3D9SYS1;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:REE99183.1};
GN ORFNames=DFJ69_4690 {ECO:0000313|EMBL:REE99183.1};
OS Thermomonospora umbrina.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Thermomonosporaceae; Thermomonospora.
OX NCBI_TaxID=111806 {ECO:0000313|EMBL:REE99183.1, ECO:0000313|Proteomes:UP000256661};
RN [1] {ECO:0000313|EMBL:REE99183.1, ECO:0000313|Proteomes:UP000256661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43927 {ECO:0000313|EMBL:REE99183.1,
RC ECO:0000313|Proteomes:UP000256661};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REE99183.1}.
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DR EMBL; QTTT01000001; REE99183.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3D9SYS1; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000256661; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000256661};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 22..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..533
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 629..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..331
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 705 AA; 73376 MW; 447721E22069BC32 CRC64;
MTAVPDGPLA RLARLCHRRR RLVVLLWIVG AAAVMVVGFG NAADPLNDFS GGSSESAKAQ
QVLEDHFPGM RGDSITLAVR AERGIDDPAV KARVEQAVER LRKTPHVSEV SSPYASPQQV
SKDRKTAFAS APLDVTADDM PTEPVEELLA DVRTGPDGGL RMELGGAVVE AAETPEGGSS
EGVGLLAAVV VLLIAFGSVL AMGLPIVTAL FGIGTGLALI MLLGHLLPAP GFAPIIAALI
GLGVGIDYAL FIVTRYREEL AEGADPETAT VTAIGTAGRA VLFAGTTVVI ALLGLLVMQQ
KLLNAVAMAA GVTVLMTMLT AVTLLPALLG FTGRGIDRLR VPGLGRARRP LAEKWARAVQ
RRPAVAALLA TGLLLALAAP ALSMRLGFPD ATSQPRDSSG YNAHRILSDG FGPGYDSPLV
VVAQGGDPRP VVEAVRAAEG VADVTPARPS PDGAASVFIA YPASAGPDEA TSDLVQRLRD
DVVPRAVGDG DLRVLVGGPN AGSIDFADSV QTRLPWLIAV VVGLSLVLLM ALVRSVTIAL
QAAVMNLLSV AAAYGVLTAV VQWGWAGTAL GFPTEMPVTM WVPLMMFPIL FGLSMDYEVF
LISRIREIHL GGVETREAVA QGLARTARVI TAAAAIMVMV FLSVLLGADV EVKQMGLGLG
VAVLIDATVV RMVLVPALME LFGKANWWLP APLARLLPGR LAAAE
//
