ID   A0A3E0EN74_9FLAO        Unreviewed;       453 AA.
AC   A0A3E0EN74;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Hydroxymethylglutaryl-CoA synthase {ECO:0000313|EMBL:REG99163.1};
GN   ORFNames=C8P67_105339 {ECO:0000313|EMBL:REG99163.1};
OS   Flavobacterium aquicola.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1682742 {ECO:0000313|EMBL:REG99163.1, ECO:0000313|Proteomes:UP000257136};
RN   [1] {ECO:0000313|EMBL:REG99163.1, ECO:0000313|Proteomes:UP000257136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100880 {ECO:0000313|EMBL:REG99163.1,
RC   ECO:0000313|Proteomes:UP000257136};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:REG99163.1}.
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DR   EMBL; QUNI01000005; REG99163.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3E0EN74; -.
DR   OrthoDB; 9769523at2; -.
DR   Proteomes; UP000257136; Unassembled WGS sequence.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
FT   DOMAIN          19..173
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          226..410
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   453 AA;  50941 MW;  9A609B8EABC3A5D1 CRC64;
     MKTGIDAIAF DVAKLHLPIK TLATARNIEP EKLEKGLGLL KMTLPDTHQD TVVFGANALT
     KLILDNNIKL DEIARIYVGT ESGIDSSKPI GSYLISLIEQ KFGENTLSEC DVVDFTFACI
     GGVDAMQNCL DFVQLNPTKK AIVVASDFAK YDLNSTGEYT QGAGAVAMLI SSNPRIITFE
     NNWGVSTKGV FDFFKPYRTI SKQEITGNAD NDSWFDNLES EIEIHKDQPV FDGQYSNQCY
     MDRTREAYFS FKKLKNTSGT VYDSWKSIVM HLPYAFQGRR MLSEIHALDA STAVITGEEN
     ASEYQNKLKE ISKSDDYKTF VSEKLQPAEL ASSLIGNLYT GSIFMGLLST LAHFYDSKKE
     IADEKFGFLA YGSGSKSKVF EGTIQPEWKS AVSSVLLFET LEKSFEIDFE TYEKLHKKEQ
     KQSIQQPKNE WILDRIETEI PTLIGARYYK WVD
//