ID   A0A3E0EU22_9FLAO        Unreviewed;       796 AA.
AC   A0A3E0EU22;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:REH01693.1};
GN   ORFNames=C8P67_101174 {ECO:0000313|EMBL:REH01693.1};
OS   Flavobacterium aquicola.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1682742 {ECO:0000313|EMBL:REH01693.1, ECO:0000313|Proteomes:UP000257136};
RN   [1] {ECO:0000313|EMBL:REH01693.1, ECO:0000313|Proteomes:UP000257136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 100880 {ECO:0000313|EMBL:REH01693.1,
RC   ECO:0000313|Proteomes:UP000257136};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:REH01693.1}.
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DR   EMBL; QUNI01000001; REH01693.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3E0EU22; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000257136; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027}.
FT   DOMAIN          7..205
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          208..307
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   796 AA;  88101 MW;  6C532E3A320BB09B CRC64;
     MKRSIKKVAV IGSGIMGSGI ACHFANIGVE VLLLDIIPNA LTDAETKKGL TLESKIVRNR
     VVNEHLANSL KSKPSPIYGQ KFASRITTGN TTDDMAKIAN VDWIIEVVVE RLDIKKLVFE
     QIEKFRKPGT LVTSNTSGIP IHFMSEGRSE DFQKHFCGTH FFNPARYLKL FEIIPGPQTS
     SEVLDFLTIY GEKFLGKTSV VAKDTPAFIG NRIGIYGIQS LFHLVKELGL TIEEVDKLTG
     PVIGRPKSAT FRTVDVVGLD TLVHVANGIY ENCPSDEQHE LFKLPDFVSK MMENKWYGSK
     TGQGFYKKVD KDILSLDLDT LEYRPAKRAS FATLELTKTI DKPINRFKVL VKGKDKAGEF
     YRKSFAGMFA YVSNRIPEIS DELYKIDDAM KAGFGWENGP FEIWDAIGVA NGIEIMKAEG
     LEPAAWVTEM IASGSSSFYT VKEGATYFYN VPTKSQTKVP GQDSFIILNN IRESKKVWSN
     SGAIIQDLGD GILNLEFQSK MNTIGGDVLQ AINKAIDLSE KEYQGLVIGN QAANFSVGAN
     IGMIFMMAVE QEYDELNMAI KMFQDTMMRV RYSSIPVIVA PHGMTFGGGC EMSLHADKVV
     AAAETYMGLV EFGVGVIPGG GGSKEMALRA SDLFRKNDVE LNVLQEYFLT IAMAKVSTSG
     YEAFDTGLLQ HGKDIIVVNK DRQIAEAKKH ALLMAEGGYT QPIRRTDVKV LGKQALGMFL
     VGTDQMEAGK YISEHDKKIA NKLAYVMAGG DLSESTLVSE QYLLDIEREA FLSLCTERKT
     LERIQYMLTK GKPLRN
//