ID A0A3E0GVW6_9PSEU Unreviewed; 1028 AA.
AC A0A3E0GVW6;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Condensation domain-containing protein {ECO:0000313|EMBL:REH27643.1};
GN ORFNames=BCF44_12931 {ECO:0000313|EMBL:REH27643.1};
OS Kutzneria buriramensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1045776 {ECO:0000313|EMBL:REH27643.1, ECO:0000313|Proteomes:UP000256269};
RN [1] {ECO:0000313|EMBL:REH27643.1, ECO:0000313|Proteomes:UP000256269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45791 {ECO:0000313|EMBL:REH27643.1,
RC ECO:0000313|Proteomes:UP000256269};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REH27643.1}.
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DR EMBL; QUNO01000029; REH27643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3E0GVW6; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000256269; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..431
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 556..630
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1028 AA; 110471 MW; 2E6C3D37536236D3 CRC64;
MNAGESIAVI GMAGRFPKAG DLDEYWANLV AGRDCLDDLG EGELRANGVP EGVLRNPDYV
RRAASLAGFA EFDAEFFGFA PGMAAALDPQ QRLFLESCWH ALEDAAYLPS VVDGAIGVFG
AGSFTGYLQH TLLSQRDPRQ FLDTGTSTAV VEALTMGDNN FFATRVAHTL NLHGPALTVQ
TACSSSLVAV HLACQSLLLG ECDMALAGGM TVKVPHRVGY VHDIDSMMSA DGRCRPFDAA
ANGTVFGSGG GAVVLKRLSD AVADKDNVRA VIRGSATNND GSLKMGFAAP SVRMQSAVVA
EALAVAGFEP QDIGYVEAHG TGTTLGDPVE MAALRTALPT AEDCVVSSVK GNIGHLEAAS
GIAGLIKAVL ALENGWIPGT AHFTEPNREL RLDDSPFVVR ADGTGWGERP KIAGVTSLGM
GGTNAHVVVA ETPRRPERPA DQRPSVLVLS ARNQNALTDM RQALAAHLRR KPEIPLADVA
HSLSVGRHQF EHRFAVMAST AAEAVDLLES GQGLADPQPV PANPDAMRVS LPGYAFQREH
HWIEPRATAV VQASPAIPGD HRDVLADLWR ETLGVDDVAP NDSFFEQGGD SVMATAFVSR
ARTQGIDMRP KDLFDNSTFD SLVAHVEART APVAQPVEDR RIPLTPTQLW YLSASGHRQT
PLLFRLAPDL DRAIVQRAVA AVTARHDALG LVPTMSHGVW YQERRELRRE LPLVTADVDS
LKTADAVLDL VGETAFVDTV DAVFLAVVVN QVDRASARIL TEELITACDH LLAGNAVTLP
ETTAWARWAR YTQDLVNDQS LFAELDHWTA TLDVPPDGLS VSNPAGPWQV LRYAAKAEPL
TAVRRRAQAK WAELLLTAMT SAWHRLTGRT TMTVDVLGSV RQANPAMSLD RSVGLYSAIY
PVTFTAAENR LDAVRQSWRD VPRHGLGYGV LRHLYGPTAE RFRDLPEPSV LFAAQGAVGR
PVRASRQPLS RMALDVAPTG RHPVEVRCHT ADGAFVVEWW HDPDRCDTAL LAAWNDQTAV
VLDALASP
//
