ID A0A3E0H125_9PSEU Unreviewed; 5762 AA.
AC A0A3E0H125;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Non-ribosomal peptide synthase protein (TIGR01720 family)/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:REH36226.1};
GN ORFNames=BCF44_11695 {ECO:0000313|EMBL:REH36226.1};
OS Kutzneria buriramensis.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Kutzneria.
OX NCBI_TaxID=1045776 {ECO:0000313|EMBL:REH36226.1, ECO:0000313|Proteomes:UP000256269};
RN [1] {ECO:0000313|EMBL:REH36226.1, ECO:0000313|Proteomes:UP000256269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45791 {ECO:0000313|EMBL:REH36226.1,
RC ECO:0000313|Proteomes:UP000256269};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:REH36226.1}.
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DR EMBL; QUNO01000016; REH36226.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000256269; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17652; A_NRPS_CmdD_like; 2.
DR CDD; cd12117; A_NRPS_Srf_like; 2.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19534; E_NRPS; 3.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 3.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 14.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 513..588
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1513..1587
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2891..2965
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4285..4359
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5673..5748
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 5762 AA; 625634 MW; BFB29776798B6964 CRC64;
MSVPPEWNAT DRPVPARTLA QLVEGQVART PDAPALLGAD GMVTFAQLDA RANRLAHLLA
ARGAGRERIV ALALPRSADL VTAQLAVAKT GAAFLPVDPD YPKERISLMF DDADPVLVVT
RRALAERLPA GSNSAVPMIT LDTPGLLEDR PDHELPVSPQ CTDHAAYVIF TSGSTGRPKG
VVVTHAGLAS FAAAEMDRYE VRAGDRVLQF SSPSFDASIL ELCMSLPAGA ALVVPPPGPL
LGDRLAEVLQ GERITHALIP PVALATVPDM KLPDFRTLIV GGDACTADLV RRWAPGRRMI
NSYGPTESTV VATWSDPLTP GGTPPIGRPI WNTKARVLDD QLRPVAFGVT GELYVEGIGL
ARGYLERPGL TAARFVASPF TPGARMYRTG DLVRWTAEGV LEFVGRADHQ VKVRGFRVEL
GEIESALRAH QHVRDAVVIA REDRPGVKRL VGYVIADTDA DLRTHLAASL PDYMVPAVIM
RVDAFPLGPN GKLDRKALPE PDWAKARRSR YVPPRTEAER VLAELWGDLL GVAEIGVQDD
FFELGGDSIL GAKLLARIRT SFDVDLSPRV VFDARTVAGI AELLPPQAHA AGDRIRRVPR
TSPIPISPAQ RRLWLLNDLT AGDTEYNSAI GLRLRGRLNP MALQKALDAL AERHESLRTT
FDIVDGEVVQ VIGQHGSLPL QRIDDIEAEL EQPFDLSEGP LTRVSLIELA ADDHVLLLCQ
HHIITDGWSV ALLIDELITL YTGGELPAPT IQYADFARWQ QERLTGRLKD RQLAYWRRKL
AGLAPLELPT DRPRPQVRTT AGSIRRYDLP ADLVHRLTEI GQDHGATLFM TLTAAVQLLL
ARHSNQQDVA LGTVVSGRDH AELEQVAGFF VNTLVLRSWV DPAQAFPDFL ADARETVLEA
FAYADLPFDQ VVADLQPVRD PSRTPLAQAL IILQNAMVPA RTAGDLTVRD HDLPRPRARF
DLVFEFVPRD GGLVAAIEYN TDLFDASTID RVAGHLRVLL DGIAADPART VGELPLLNDA
ERRQVLTEWQ GPVITVPSVT LADLYEQQTE RTPNAVAVVC EGRELTYLEL NERANRLARR
LIEQGAGPER LVAISMPRSE QMIVAVLAVL KSGAAYLPVD PKYPAERREL MIADARPVVV
LTEIGDLPHS ADDLGDVGLT PAHPAYVIYT SGSTGRPKGV VITHASAVEL MAWAAKDFGA
PGLSTVVAST SLNFDVSVFE ILCPLMIGGT IEIVRDVLAL GERPGGDWQA SLVSGVPSAF
AQLLAQGAVS VTPEHVVLAG EALTASAVRD VRKALPGVKV ANIYGPTEAT VYATAWYDDG
TDRNPPIGRP IANTRAYVLD SAFRPVPPGV TGQLCLGGTG LARGYLNRGG LTADRFVADP
FGPAGSRMYL TGDVVRWTAD GELEYLGRAD HQVKIRGFRI ELGEIENAMR AHPNIVDAVV
VVREDNGHKR LVGYVVGDGR ADLRAHLAKS LPEYMVPAGF VFLDQFPLNP NGKLDRAALP
APDWEAQGED YVAPRTDTER VLAEIWAKVL GIARVGVLDN FFELGGDSIL SIQVVSKAAQ
AGLTVSSRDV FLNQTIAALA TTVVAGERIE RGPATGEVPL TPVQRWFLDT EPATPGHFTQ
SVVTRFDEPI DAERLAKALQ ALVDHHDMLR ARFTDRQVIP TAEPVTVLGE PDPVFDLTSG
PLIRAAITGP DQVTLYVHHL VVDGVSWRIL VEDLHTAYDG GDLGHRTTSF QEWAHRLRNH
TFDDVAYWQA IEDVPVPVDG HGPDTVADTR EVGFNLDAEQ TRALLQDVPG VYRTQVNDVL
LAALGKALTA WTASPRVVVD LEGHGREDLF DGVDVSRTVG WFTSIFPVSL EITGDWSRDL
KAVKEQLRSV PSRGVSYGAL RYLTGSVPAI EPAVSFNYLG QFDGAGEMAL SEDPAAPRRH
LLDVVGRVEN GCLEFTLFHG ANHRTATIEG LAAAMRGALL EIIEHCGQPG AGGRTPSDFP
LAALDQSTVD RLVGDGRGVE DVYPLTPTQA GMVFHRLVEK GQGAYFQQVS FVVDAGADEL
VAAWQTVVDR TPVLRSDIVW EGVDRPLQVV RRGVTLPIRR YAGSFEDLLA EDRAAGLDLT
RAPLMRITLV DEPGGTQVLW TFHHLLLDGW SLFQVLGDVM AAVSGSEPAI RRPFRDYVAW
LSTQNTAKAE EFWRGMTCDR TPLPFDRQPG GVTESTASLR IVFPADSLRA MAQRNGLTVN
TVVQGAWALL LARHSGQRRV CFGSTVSGRP AALPGVDEIT GIFIATLPSV VDVDEKQALV
PWLRRIQDEQ AEARRFDFAP PTGNLFDSIL VFENYPVDAD LGVRELRGVE TTNYPLAVVA
YPGDNLTLAF GYDPNLFDES TIAGLAGRLR TLIEEIAAET DRPLAAVPML SDAERNLLLH
KYNNTAHPLP ELSVVELFAA QVRRRPDELA VDDLTYEELD RRSNRLAHRL IELGVDRDRP
VALLLERSPE LVVAELAVLK AGGAYLPLDA RAPKDRLRTL AADAVVLITD ATWCETAANV
HDGRIALIGE GRNESPVEVS VHPANLAYLM FTSGSTGVPK AVAVTHRDIV GLAADRSFRR
GHKTVLLHSP QAFDASTYEL WVPLLNGGRV VVAPPGTVDA SVIRWAIDQG VTGMFLTIGL
FRLVAQEDPE CFNRLAEVWT GGEVVPAEAL RRVLAACAGL SVVDVYGPTE TTTFASRHVM
TDVVPNVVPI GSPLDNMRLH VLDGDLRLVP PGVTGELYIG GVGVARGYYG QPGLTAARFV
ADPFGTGERL YRTGDLVRWR DGVLEFVGRA DDQVKIRGFR IELGEIEAAL AAHPDVEQAV
VAVRTDDGRK RLVGYVVGAA VNVSEWLADR LPDYMVPAVI VRLESLPLNA TGKVDRKALP
APEITERGYV APGTDAERTL ASIWAEVLRL PRVGVEDNFF ELGGDSIVSI QVVSRARQAG
LSLMPGDLFA HPTVAALAAA AGTATAVTAS QDAVTGEAPL TPVQHWFLDA DPVHAEHFTQ
SMLLDLDGDR DALDRALNVL LAHHDALRTR FDGRQITRPV GSTRILDGAE FDLVDGPLFR
ASIVDGKLLI EAHHLVVDTV SWRILAEDLA AALRGDELPA KTTSFQEWSR RLAAFAESGG
FDDELDHWKS LATSSPLPVD AGGVNTQGSV RTITVSLDAE RTRALLQDVP GVYRTQVNDV
LLSGLARALT DWTGRDSVLV DLEGHGREQL FDDVDLSRTV GWFTSIFPVE LAVGADWDET
LKAVKENLRA VPRRGVGYGA LRHLTGAAPA INPEISFNYL GQFTGDGSIG GSADPAQHRP
HLLDVVALVQ HDRLDLTWYY SDQVHTEATV CRLADAMVEA LTDIVRHCAR PGVGGRTPSD
FPLARLSQSD VDGLVGDGRS VEDIYPLTPL QAGMIFHSLV DGSSGAYFNQ VQLQLTGVED
VQRFAEAWQR LVDRTPVLRS RIVWDGLAEP VQVVQRDVTL PVSMLDWTTG GIDSKLRELL
DNDRALGLDL AAPPLMRVTL AKLAADEVLL VWTFHHVLLD GWSCAQLVSE VCADYKAVGT
PPRRTPFADY LRWLSTQDIY AAETFWRSAL RNVEGPTPLP FDRQPVESHR AQSCATVRVE
YASGQLTELA QRLGLTVNTI VQAAWGLLLA RRAGVDDVVF GTTVSGRPAD LPGVESMVGM
VINTLPSRIR LDGGKSVADW LRGVQQELSQ ARQYDFVSLA QLQGWVGTTL FDSLLVFENY
PFDEEAIAAQ GIGMHGMGEV QPTNYPLSVV VQPGRSLEVS FDYDPTLFDE STIRGLADQL
ELVLAAVTGG PERPVRELDL LTDEDRRLVR HEWNATATAP SFDTVLTAFA RQDPDAPAVD
SLTYAELDAR ANRLANRLIK LGVGVEDRVG LRVERSVDLV IAELAVLKAG AAYVPIDLRA
PAQRQQAVLE QAGVDIVITD GEIDVEEPST APEVRVNRSN LAYVMFTSGS TGVPKGVAVT
HADIVELARD RSFATGHTTT LLHSPQAFDA ATYEVWVPLL NGGRVIVAPP GDVDASVIRW
AVGQGVTGMW LTAGLFRLIA QEDPACFTGL TEVWTGGDVV PAEAARRVIS SGVSVVDGYG
PTETTTFASR YKMCGEVPDS VPIGSPLDNM RLYVLDGDLR LVPPGSTGEL FIGGAGVARG
YIGRPGMTAA RFVADPFNSG ERLYRTGDLV RWRDGVLEFV GRADDQVKIR GFRVELGEIE
TVLAAHPAVD QAVVIVRADD GRKRLVGYVV GETQDLKEWL AERLPDYMVP AAIVAMDELP
LSRNGKVDRK ALPAPELAAS SGYLPPRTDN ERILAGIWAE ILGTEKVGVE DNFFELGGDS
ILSIQVVSRA RAAGLNLTPR DLFAHPTVAA LAANATAAVQ IVAEQGAVTG EVPLTPIQRW
YLDDAVAPES FTQSMRIEWP QDIDPDQLRT ALSTVVSHHD ALRLRFHRID GTWWQHNAPD
EAAQILDAEI DLADGPVITA KIVEPNVLVL TAHHLVVDGV SWRVLIEDLE AAYHRKTLPP
KTTSYREWAH RLAQRDFGAE IPFWTSMAAD PTLPTDGNGP NTYATTTTVT VGLDAIQTRA
LLQDVPGVYR TQIDDVLLAA LGRVLADWTG RQHVLVDLEG HGREQLFDDV DLSRTVGWFT
SMYPVELAVG ADWAETLKSV KEQLRAVPNK GVAGLIHATA EPRISFNYLG QFTDAGTLDS
DIGPDERRPH QLDVVGVVQG GKLELTWQYS TNLHRGSTVR RLAGDLVAAL HEIIRHCAEP
GAGGRTPSDF PLAGLAQHQV DRIAGDGRDV EDIYPLTPMQ AGMVFHGLSQ QDRGLYFEQV
AFVLTDSPDM QRLAESWQRV VDRTPVLRSR IVWDGVPEPM QVVDRHVKVP IARYDWHGLD
REAMLEDLLA SDRAKGFDLA AGPLLRITLA RLSATEVQLV WSFHHVLLDG WSVFQVLSDV
LGTAEQRVRR PFADYVAWMR RQDVQAADRH WRDVLADIEG PTPLPFDRTP TSSHDTASTE
WVSARLDQGA AGRINEFARR RRLTVNAVVQ GAWALLLSRY SGQGDVCFGA TVSGRPADLP
GADDIAGIFI NTLPVRTAVD SRLSVVDWLQ EMQQAQAESR RFEYVPLSRL QSLVGLPSLF
DSAVVFENYP VGEQQGIRDL DATEATNYAL TVVGVPGETL TLGIGYDPEL FDVGTVQRMV
GHLVRVVEAM CDNPTLGEID VLTDRERFHL LTGVNATDRV VVPATLPELI EAQADRTPDA
PAVLADTTLT FAELDRRANR LARRLIAAGA GPETIVALAL PRSLEIIVAQ LAVLKAGAAY
LPIDPAYPAE RIQFMLDDAE PVLVVGGDFA MDGSEASYSD EPVTRSLSPA SPAYVIYTSG
STGRPKGVVV THAGLASFSA AEIEHFDVRP GDRVLQFASP SFDASVLELC MSLPAGAALV
VPPAGPLLGE HLAAVFSSRE VTHALVPPVA MATVPDVALP SLRTLILGGD ACTPDLVARW
APGRRLINAY GPTESTVVAT WSDSLEPGGT PPIGRPIWNT RAYVLDDELR PVPVGVPGEL
YVAGIGLARG YLDRPGLTAS RFVANPFTPG ARMYRTGDLV RWNADDQLEF LGRADNQVKI
RGFRVEPGEI EAALTARSDV RAAAVIGADQ RLVAYVVGET DGLREYLGAR LPEHMVPAVF
VPLAELPLTP NGKLDRKALP APAQELPTTG YTAPETETEE VLVGIWAEAL QLERVGVTDN
FYDLGGDSVR SLHITSMVRT AFDVELTPRD VLASGTVAAL AELIEERVLL ELERVAFGDE
EI
//
