ID   A0A3E0H7F8_9PSEU        Unreviewed;       597 AA.
AC   A0A3E0H7F8;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Pyruvate dehydrogenase (Quinone) {ECO:0000313|EMBL:REH39382.1};
GN   ORFNames=BCF44_113237 {ECO:0000313|EMBL:REH39382.1};
OS   Kutzneria buriramensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Kutzneria.
OX   NCBI_TaxID=1045776 {ECO:0000313|EMBL:REH39382.1, ECO:0000313|Proteomes:UP000256269};
RN   [1] {ECO:0000313|EMBL:REH39382.1, ECO:0000313|Proteomes:UP000256269}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45791 {ECO:0000313|EMBL:REH39382.1,
RC   ECO:0000313|Proteomes:UP000256269};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT   (KMG-II): from individual species to whole genera.";
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:REH39382.1}.
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DR   EMBL; QUNO01000013; REH39382.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3E0H7F8; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000256269; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:REH39382.1};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          4..120
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          199..329
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          389..544
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          171..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   597 AA;  64378 MW;  8C81B79DC534A5C5 CRC64;
     MAETVGDYLL GRLRDWQVDQ VFAYPGDGIN GIVAAFGRAD DTPRFIQARH EEMAAFEAVG
     YAKFSGKVGI CMATSGPGAI HLLNGLYDAK LDHVPVVAIV GQTARSAMGA SYQQEVDLQS
     LFKDVASAYL VEVNVPEQLP NALDRAIRVA EAERTPTAVI IPSDLQEQPY SPPQHVFKQS
     PSSPPSHPHT VTVPDLAEIE RAADVINAGS KVAILCGQGA RAAADEVRQL AELTGAGVAK
     ALLGKDVLPD DLSYVTGSIG LLGTRPSYEL MTGCDTLVII GSNFPYSQFL PEYGKARAIQ
     IDIDGKFIGM RYPTEVNLVA DAKATLAALL PKIERKGDRS WRETIESNVA KWWETMERES
     MVDADPVNPM RITWELSACI PDNAIVTSDS GSAANWYART LKMRAGMRGS LSGTLATMGP
     GVPYAIGAKF AHPDRPAIAL VGDGAMQMNG LAELITIKRY YERWSDPRCV ICVLHNNDLN
     QVTWELRAMG GAPKFEESQV LPDIDYAAIA RSFGLGGIVV TEPDRLGAAW EEAFAADRPV
     VLDVHCDPNV PPIPPHATFE QVKAAAESVL KGDPDAFGLV TQGIKTKLQE FVPGSRK
//