ID A0A3E0VHR7_9MICO Unreviewed; 1012 AA.
AC A0A3E0VHR7;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cell division protein FtsK {ECO:0000313|EMBL:RFA08920.1};
GN ORFNames=B7R54_06540 {ECO:0000313|EMBL:RFA08920.1};
OS Subtercola boreus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Subtercola.
OX NCBI_TaxID=120213 {ECO:0000313|EMBL:RFA08920.1, ECO:0000313|Proteomes:UP000256486};
RN [1] {ECO:0000313|EMBL:RFA08920.1, ECO:0000313|Proteomes:UP000256486}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K300 {ECO:0000313|EMBL:RFA08920.1,
RC ECO:0000313|Proteomes:UP000256486};
RA Cho Y.-J., Cho A., Kim O.-S., Lee J.-I.;
RT "Comparative genome analysis of Subtercola boreus.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Required for activation of the Xer recombinase, allowing
CC activation of chromosome unlinking by recombination.
CC {ECO:0000256|ARBA:ARBA00024986}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFA08920.1}.
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DR EMBL; NBWZ01000001; RFA08920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3E0VHR7; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000256486; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:RFA08920.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000256486};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..797
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1012 AA; 106631 MW; FEE8BEA9C841A0E1 CRC64;
MATSTRANSR ARGAAGGRGG ASGAGAAGGG NGGGANGGRR APAKTPAKQQ ATATQKTLKF
PVESEGPGIF TTMWLGLAHL VGGAARAFGH EKLAKEERRD GFPFLLFLLA VAGAVIEWFL
VASPVANLLD AYTFGGLFGR VAYALPVVML LLAIWLFRHP NSVNDNGRIG IGLGILLLMV
SGLCHIFGGE PYPAEGMESL ATAGGVFGWV IAAPLILIIT PIGATIVVCA LLLLSLFIIT
KTPPNKLASR SRELYAYLFG AAFGEAPESR EDREPKVPRA GRGRNVEHTG DLELDFDHVN
DESLPWWRRN KSGREEDPAF DSPIIPTTAV GPAPIHVEDR TPPTEVIDRT IDESRGFDAA
LLGDMEAAEQ AVRRFTGEVL PGTKSATGIR DDAAGDSASF TGVLFGETSG AAGAVGAAAA
GAVPATKPFP TAATAVPDAL PGLSPDDTFI PLAEVKELEA LNYSLPPVGS LALGEPSKAR
SQANDDIVRA LTDVLSQFQV DAKVTGFSRG PTVTRYEIEL GPGVKVERVT ALSKNLSYAV
ASNEVRILSP IPGRSAIGIE IPNTDREIVV LGDVLRSAKA TNDTHPMTIG VGKDVEGKFI
IANLAKMPHL LVAGSTGSGK SSFVNSMVTS ILMRATPAEV RMVLIDPKRV ELTAYQGVPH
LITPIITNPK KAAEALAWVV KEMDMRYDDL ESFGFRHIDD FNRAVVNKEL VLPAGSSRVL
KPYPYLLIVV DELADLMMVA PRDVEDSIVR ITQLARASGI HLVLATQRPS VDVVTGLIKA
NVPSRLAFAV TSVTDSRVIL DQPGADKLIG QGDALFLPMG ASKSIRVQGA WVSESEIAKV
VEHVTRQARP EYRQDVTAAA ASKQIDSDIG DDLEVLLQAA ELVVNTQFGS TSMLQRKLKV
GFAKAGRLMD LLESREIVGP SEGSKARDVL VTADQLPEVL AMLRGSDAAA APSSPAGPSQ
PSQGAPAAGL SPAAGYGTDQ MDYSDPLAEP GPGYPEVEGD TDEDAWGLTG RE
//
