ID A0A3E2GXE0_SCYLI Unreviewed; 1059 AA.
AC A0A3E2GXE0;
DT 16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT 16-JAN-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=ATP-dependent RNA helicase DBP2 {ECO:0000256|ARBA:ARBA00039329};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATP-dependent RNA helicase dbp2 {ECO:0000256|ARBA:ARBA00039605};
DE Flags: Fragment;
GN ORFNames=B7463_g10664 {ECO:0000313|EMBL:RFU25677.1};
OS Scytalidium lignicola (Hyphomycete).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Scytalidium.
OX NCBI_TaxID=5539 {ECO:0000313|EMBL:RFU25677.1, ECO:0000313|Proteomes:UP000258309};
RN [1] {ECO:0000313|EMBL:RFU25677.1, ECO:0000313|Proteomes:UP000258309}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 105466 {ECO:0000313|EMBL:RFU25677.1,
RC ECO:0000313|Proteomes:UP000258309};
RA Buettner E., Gebauer A.M., Hofrichter M., Liers C., Kellner H.;
RT "Draft genome sequence of Scytalidium lignicola DSM 105466, a ubiquitous
RT saprotrophic fungus.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent RNA helicase involved nonsense-mediated mRNA
CC decay and ribosome biogenesis through rRNA processing.
CC {ECO:0000256|ARBA:ARBA00037752}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC subfamily. {ECO:0000256|ARBA:ARBA00009334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RFU25677.1}.
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DR EMBL; NCSJ02000315; RFU25677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3E2GXE0; -.
DR STRING; 5539.A0A3E2GXE0; -.
DR OMA; EYREAMM; -.
DR Proteomes; UP000258309; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0050334; F:thiaminase activity; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd17966; DEADc_DDX5_DDX17; 1.
DR CDD; cd01169; HMPP_kinase; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd19367; TenA_C_ScTHI20-like; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 1.20.910.10; Heme oxygenase-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR016084; Haem_Oase-like_multi-hlx.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR InterPro; IPR004305; Thiaminase-2/PQQC.
DR InterPro; IPR027574; Thiaminase_II.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR NCBIfam; TIGR04306; salvage_TenA; 1.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF150; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF03070; TENA_THI-4; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48613; Heme oxygenase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000258309}.
FT DOMAIN 633..661
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 664..839
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 867..1014
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1037..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 633..661
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RFU25677.1"
FT NON_TER 1059
FT /evidence="ECO:0000313|EMBL:RFU25677.1"
SQ SEQUENCE 1059 AA; 114802 MW; 2FCAA7A218887007 CRC64;
MSKGRVLVIA GSDSSGGAGL EADQKVIAVH GCYAMTVTTA LTAQNTQGVV DIHYIPPDFV
RKQIDACISD IGVDVVKTGM LASAETIKVV SKSLLHHNVN TIVVDPVMVS TSGSVLLPQE
AIRELRELLL PRSTIVTPNV PEAKLLLSDA GIHVDEPNNV QDLVEIAKKV QSLGPKYVLV
KGGHLPLKKD GTRASTDSEN EIIVDIIYGE GIVTRLEAPF QVSKNTHGTG CSLASAIASN
IANGMDMVTA VKGHFIEYLL DRSDVKDAWQ GHVEHDFVAR LADGTLPLEM FKYYLIQDYL
YLIQFARANA LASYKAKTGE DIAAAASIVS HIFHEMKLHI DYCEGFGVSK AQIEASEESQ
ACTAYTRYVL DIGQSEDWIA LQISMAPCLI GYGDIAQRLF NDPETKREGN IYWKWIENYA
ADDYVEAVRI GSELIERHMV LQSPSRIEEL VKIFIHATNM EKGFWDMGSG KTSICRTEED
TVVLEVVAED TQMAMIVMAV GEAATLMGMI HDDSDIIMKF DASSVMDCGS NGYSNGGGGG
GGGYGGNVNG FSGGGGGGYG GGGGYGGSGG DRMSNLGAGL QKQNWDFNTL PKFEKSFYKE
DPQVAARSDA DVAAFRAKHA ITINGQDVPK PVETFDEAGF PAYVMSEVKA QGFPAPTPIQ
SQGWPMALSG RDVVGIAETG SGKTLTYCLP AIVHINAQPL LAPGDGPIVL VLAPTRELAV
QIQQEITKFG KSSRIRNTCV YGGVPKGGQI RDLAKGVEVC IATPGRLIDM IESGKTNLRR
VTYLVLDEAD RMLDMGFEPQ IRKILSQIRP DRQTCMWSAT WPKEVRALAS DFLNDFIQVN
IGSMELSANH RITQIVEVVS EFEKRDKMTK HLEKIMEDKD NKILIFTGTK RVADDITRFL
RQDGWPALSI HGDKQQNERD WVLNEFKTGK SPIMVATDVA SRGIDVRNIT HVFNYDYPNN
SEDYIHRIGR TGRAGAKGTA ITLFTTDNQK QARDLVSVLT EAKQYIDPRL LEMTRYGGGG
GGGGRYGGGY RGGRGGHGGR GGGGFSGSNA APLGGSRRW
//
