UniProt: A0A3E2H024

Database: UniProt
Entry: A0A3E2H024_SCYLI

LinkDB:  A0A3E2H024_SCYLI 
Original site:  A0A3E2H024_SCYLI

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (15)   
   InterPro (10)   
   Pfam (3)   
   SMART (2)   
All databases (25)   

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ID   A0A3E2H024_SCYLI        Unreviewed;      2233 AA.
AC   A0A3E2H024;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=DNA polymerase epsilon catalytic subunit {ECO:0000256|RuleBase:RU365029};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU365029};
DE   Flags: Fragment;
GN   ORFNames=B7463_g9716 {ECO:0000313|EMBL:RFU26627.1};
OS   Scytalidium lignicola (Hyphomycete).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Scytalidium.
OX   NCBI_TaxID=5539 {ECO:0000313|EMBL:RFU26627.1, ECO:0000313|Proteomes:UP000258309};
RN   [1] {ECO:0000313|EMBL:RFU26627.1, ECO:0000313|Proteomes:UP000258309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 105466 {ECO:0000313|EMBL:RFU26627.1,
RC   ECO:0000313|Proteomes:UP000258309};
RA   Buettner E., Gebauer A.M., Hofrichter M., Liers C., Kellner H.;
RT   "Draft genome sequence of Scytalidium lignicola DSM 105466, a ubiquitous
RT   saprotrophic fungus.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA polymerase II participates in chromosomal DNA
CC       replication. {ECO:0000256|RuleBase:RU365029}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU365029};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU365029};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365029}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU365029}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFU26627.1}.
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DR   EMBL; NCSJ02000251; RFU26627.1; -; Genomic_DNA.
DR   STRING; 5539.A0A3E2H024; -.
DR   OMA; MLDQCRY; -.
DR   Proteomes; UP000258309; Unassembled WGS sequence.
DR   GO; GO:0008622; C:epsilon DNA polymerase complex; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05779; DNA_polB_epsilon_exo; 1.
DR   CDD; cd05535; POLBc_epsilon; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR013697; DNA_pol_e_suA_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR029703; POL2.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10670:SF0; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT 1; 1.
DR   PANTHER; PTHR10670; DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF08490; DUF1744; 1.
DR   SMART; SM01159; DUF1744; 1.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU365029};
KW   DNA replication {ECO:0000256|RuleBase:RU365029};
KW   DNA-binding {ECO:0000256|RuleBase:RU365029};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU365029};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU365029};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU365029};
KW   Metal-binding {ECO:0000256|RuleBase:RU365029};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU365029};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365029};
KW   Reference proteome {ECO:0000313|Proteomes:UP000258309};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365029};
KW   Zinc {ECO:0000256|RuleBase:RU365029};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU365029}.
FT   DOMAIN          1522..1916
FT                   /note="DNA polymerase epsilon catalytic subunit A C-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM01159"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1233..1253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:RFU26627.1"
FT   NON_TER         2233
FT                   /evidence="ECO:0000313|EMBL:RFU26627.1"
SQ   SEQUENCE   2233 AA;  255943 MW;  6020314E1DF37323 CRC64;
     MAGTRRPQNG YRRGGKQAYY GPRKTKTFAA TGRSEATSAD ERRESNRLAH SIDEAMGFAR
     YESGKKKVGW LVNIHTTSIE DEKIPDGRSA VDCYFIEEDG GTFKATVEYE PYFLVAVRRG
     HEPEAEEWLK RSPGGGVVKH IRRIEKEDLK MPNHLLGYKR TFLELRFSNI NDLLAARRDI
     MPIAEKNKKN MNAMDTYAEV ASANAGFDLF DDSRDDDRRL NTSVADASDF IVDIREWDVP
     YHVRVMIDLD IRTGKWYTVE AKHGTTTVKC IEERLQIADP VVMAYDIETT KLPLKFPDAA
     VDQVMMISYM IDGQGFLITN REIVSEDIDD FEYTPKPEFE GPFMIFNEPD EKACIERFFL
     HIKEARPTVI ATYNGDFFDW PFMDARASVN GIDMYQEIGW RKNNADDQYM CDYSIHMDCF
     HWVNRDSYLP QGSRGLKAVT TAKLGYDPDE LDPELMLPYA SEKPQTLAEY SVSDAVATYY
     LYMKYVHPFI FSLCTIIPLG ADAVLRKGTG TLCEMLLMVQ AYQKNIVLPN KHVSPKESFW
     DGHLLDSETY VGGHVESIEA GVFRSDIPVN FAVDPKAIDE LLGDLDAALK FSITVEEKKS
     LDDVTNYDEI KQKITDQLNN LKATSNRSER PLIYHLDVAS MYPNIMTTNR LQPDSMIQES
     DCAACDFNRP GKTCDRRMPW AWRGEYLPAK RDEYNMVRNA LENEKFPGKY PNGPLRTFQE
     LSPDEQAALV RKRLQLFSQK IYHKIHDSTT IEREAIICQR ENPFYINTVR DFRDRRYDYK
     GKQKVWKGKT EALKAAAAPA AEIENGKKMI VLFDSLQLAH KVILNSFYGY VMRKGSRWYS
     MEMAGVTCLT GAHIIQMARQ LVERIGRPLE LDTDGIWCML PATFPENYAF TLKNGKKLTI
     SYPCVMLNHL VHAKFTNHQY QTLVDPATFK YETHSDNSIF FEVDGPYRAM VLPTSKEEDK
     NLKKRYAVFN HDGSLAELKG FELKRRGELK LIKIFQQQIF KFFLEGSTLA ETYASVAKVA
     NQWLDVLYSK GTTLADEELI DLIAENRSMS KTLEEYGSQK STSITTAKRL ADFLGEQMVK
     DKGLNCKYII CARPKNAPVT ERAVPVAIFS AEMSVKQHFL RKWLKEDPSD MDPRALLDWD
     YYLERLGSVI QKLITIPAAL QKIRNPVPRI AHPEWLQRRI NVKDDKMKQK KMTDLFSKTP
     LEDITNLQDP RVGDIEDFGT KLLKPKTVGS QIIASSQKSA QKRKSPEPAV PVSVNPYAAL
     PEKMPSPTED YLGFLDYQKQ KWKIQKQARI RRRHLFGESR ANAQSNIGAT FRIQAEQVYR
     NTWQVLDIRG TDSPGVVLAF VLIDSKIHTL KINVPRRVFL NLKSKELPDI EVDGCEAQKV
     THTLPNGHPS VHLFKLTMSE EVYVNEAQKM SLLFNHPSVE GVYERQVPLN IRAVLQLGSL
     CTFDETQPGV LGKGLEHGFD LSGLIRAESK QPYLSQSSLA YLYLYHVVAG DRQIFALFST
     TREQAHVIIL QKTKGSEQDI PNISKIYNDL LTRRNQEPDG NSWQSCFKYQ QKLQFKIHQV
     TTRRKALLEL SDMVKKVRNE ETKPLLLVIQ SPQRRLLVND APILGEFPIL PLRNDIDDTN
     LPPLGWQSFA TKRLVNHYLS LSSWILHLTE LARYGDVPLC NLERDDPRFI IDIAYARRLQ
     KNNVVLWWSA GPRPDHAGYE EDDVLGPLDT VQMPSVNNPG TYPSVCIELD VRNLAINTIL
     TSSLINELEG SDSISFNPAA PSDEANGDPN NVLYADNAFA SAGVTVLREM VKAWWAEACK
     GSNMADIMVQ HLVRWVESPE SFLYDRSLHY YVQIMSRKAF QQLMMDFRRV GSQVVFANAN
     RLLLQTTKSE VGNAYAYSQY ILKSIKAKPL FHFLDLEIKE YWDYLVWYDE FNYGGKACQE
     VVEAEQQTLD TIMHWQLSKF LPVSLHPIFN DWVVEFIEIM HKSKRPRVLT NGVDSTPRPT
     QLPVRNLGDD KEDKIMLGKE FEKPLKRQIA GLIRRQKDEM LHPELAGDYR FPILPGSHLK
     LENPILQLVK SLMQVLSLDK NITLEARLLR KELLAMFEVR EFSQEAYFQN PSESLKISQM
     ICDNCTMARD LDLCRDEDLI PDLDPDGKPL DSSTRPWKCS FCDSEYKRLD IEERMIASVE
     GIIVEWNTQD LKCSKCKTVR VNDFMEHCSC SGEWGGDVNR EDVVRRLKVY RNVARFYGLR
     MLDDVTEGVF AGL
//

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