ID   A0A3E2H7Y7_SCYLI        Unreviewed;       372 AA.
AC   A0A3E2H7Y7;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
DE   Flags: Fragment;
GN   ORFNames=B7463_g7142 {ECO:0000313|EMBL:RFU29203.1};
OS   Scytalidium lignicola (Hyphomycete).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Scytalidium.
OX   NCBI_TaxID=5539 {ECO:0000313|EMBL:RFU29203.1, ECO:0000313|Proteomes:UP000258309};
RN   [1] {ECO:0000313|EMBL:RFU29203.1, ECO:0000313|Proteomes:UP000258309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 105466 {ECO:0000313|EMBL:RFU29203.1,
RC   ECO:0000313|Proteomes:UP000258309};
RA   Buettner E., Gebauer A.M., Hofrichter M., Liers C., Kellner H.;
RT   "Draft genome sequence of Scytalidium lignicola DSM 105466, a ubiquitous
RT   saprotrophic fungus.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RFU29203.1}.
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DR   EMBL; NCSJ02000136; RFU29203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3E2H7Y7; -.
DR   STRING; 5539.A0A3E2H7Y7; -.
DR   OMA; STAHWFD; -.
DR   Proteomes; UP000258309; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000258309}.
FT   DOMAIN          16..285
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:RFU29203.1"
FT   NON_TER         372
FT                   /evidence="ECO:0000313|EMBL:RFU29203.1"
SQ   SEQUENCE   372 AA;  41346 MW;  64F4D83038CF4B0C CRC64;
     MASNPTQQKH SLGSVLVIGG CGFLGHNIVN LLCESYTCRV SVIDLRTIHN RRPESDGVQY
     FDADITTLSS LLPIFEKIKP DVVIHTASPT LVGGTKELYR KVNVEGTKCV IEACHKTNVK
     ALVYTSSASV VSDNASDLIN ADERWPVIAP KNQTEYYSLT KAEAEALVIA ANRSPKLLTA
     AIRPASIFGP GDVQLLPQIL RVLKNNQTRY QLGENTNLFD FTYVENIAHA HCLAARALLQ
     TYSASTAPLD YEKVDGEAFF ITNDSPLYFW DFARAVWKAG GSDKGIEQVW ELPKDLMLAA
     GAAAEWVMWL IGKRAKLTRR EVKYSCMTRY YNISKAKARL GYRPIVPLKE GIEKGVAWFI
     EQEKKDAEKK GQ
//